Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.561963
Abstract: Dendritic dysfunction is an early event in α-synuclein (α-syn) mediated neurodegeneration. Altered postsynaptic potential and loss of dendritic spines have been observed in different in vitro and in vivo models of synucleinopathies. The integration of… read more here.
Keywords: adult; integration; syn; newborn neurons ... See more keywords
α-Synuclein A53T Promotes Mitochondrial Proton Gradient Dissipation and Depletion of the Organelle Respiratory Reserve in a Neuroblastoma Cell Line
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12060894
Abstract: α-synuclein (αSyn) is a small neuronal protein whose accumulation correlates with Parkinson’s disease. αSyn A53T mutant impairs mitochondrial functions by affecting substrate import within the organelle, activity of complex I and the maximal respiratory capacity.… read more here.
Keywords: cell; synuclein a53t; a53t; syn a53t ... See more keywords