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   Articles with "a549 ddp" as a keyword



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Cisplatin‐induced alteration on membrane composition of A549 cells revealed by ToF‐SIMS

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recommendations! Published in 2019 at "Surface and Interface Analysis"

DOI: 10.1002/sia.6714

Abstract: Cisplatin has been clinically used for treatment of solid tumors such as non–small‐cell lung cancer for decades. However, tumor resistance may be acquired with losing the antitumor activity of cisplatin. As cellular membrane is the… read more here.

Keywords: a549 ddp; tof sims; membrane; membrane composition ... See more keywords
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Integration of metabolomics and transcriptomics to reveal metabolic characteristics and key targets associated with cisplatin resistance in non-small cell lung cancer.

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recommendations! Published in 2019 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.9b00209

Abstract: Continuous exposure to cisplatin can induce drug resistance to limit efficacy, however, the underlying mechanisms correlated to cisplatin resistance are still unclear. Drug-sensitive A549 cells and cisplatin-resistant A549/DDP cells were used to explore the potential… read more here.

Keywords: metabolism; key targets; a549 ddp; targets associated ... See more keywords
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Discovery of thirteen cobalt(II) and copper(II) salicylaldehyde Schiff base complexes that induce apoptosis and autophagy in human lung adenocarcinoma A549/DDP cells and that can overcome cisplatin resistance in vitro and in vivo.

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recommendations! Published in 2022 at "Dalton transactions"

DOI: 10.1039/d1dt03749h

Abstract: In this study, 13 transition metal complexes, namely, [Cu(L1H)(H2O)2]·(H2O)·NO3 (1), [Cu(LnH2)2]·(NO3)·(H2O)2 (2, n = 2; 3, n = 3; 4, n = 4; 5, n = 5), [Co(LnH)2]2·(H2O)0.5 (6, n = 2; 7, n =… read more here.

Keywords: h2o; schiff base; a549 ddp;
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A new class of nickel(II) oxyquinoline-bipyridine complexes as potent anticancer agents induces apoptosis and autophagy in A549/DDP tumor cells through mitophagy pathways.

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recommendations! Published in 2022 at "Dalton transactions"

DOI: 10.1039/d2dt00669c

Abstract: A new class of nickel(II) oxyquinoline-bipyridine complexes, namely, [Ni(La1)2(Lb6)] (Ni1), [Ni(La1)2(Lb2)] ·CH3OH (Ni2), [Ni(La7)2(Lb11)]·2H2O (Ni3), [Ni(La1)2(Lb9)] (Ni4), [Ni(La1)2(Lb8)] (Ni5), [Ni(La2)2(Lb1)] (Ni6), [Ni(La2)2(Lb6)]·CH3OH (Ni7), [Ni(La2)2(Lb11)]·CH3OH (Ni8), [Ni(La2)2(Lb3)] (Ni9), [Ni(La2)2(Lb2)]·CH3OH (Ni10), [Ni(La2)2(Lb5)]·CH3OH (Ni11), [Ni(La2)2(Lb7)] (Ni12), [Ni(La3)2(Lb2)] (Ni13),… read more here.

Keywords: a549 ddp; bipyridine; la2; ch3oh ... See more keywords
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Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway.

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recommendations! Published in 2021 at "Bioengineered"

DOI: 10.1080/21655979.2021.1971030

Abstract: Cisplatin resistance remains a major obstacle to effective chemotherapies for non-small cell lung cancer (NSCLC). Chaperonin containing TCP1 subunit 3 (CCT3) has been extensively investigated in various cancers, but not in the context of drug… read more here.

Keywords: jak2 stat3; cct3; a549 ddp; resistance ... See more keywords
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Overcoming Basal Autophagy, Kangai Injection Enhances Cisplatin Cytotoxicity by Regulating FOXO3a-Dependent Autophagic Cell Death and Apoptosis in Human Lung Adenocarcinoma A549/DDP Cells

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recommendations! Published in 2022 at "BioMed Research International"

DOI: 10.1155/2022/6022981

Abstract: Cisplatin resistance is one of the major obstacles in the treatment of nonsmall cell lung cancer (NSCLC). Kangai injection (KAI), a Chinese herbal medicine, has been used in tumors as adjuvant treatment, but its exact… read more here.

Keywords: cisplatin; ddp cells; cell; a549 ddp ... See more keywords
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Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway

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recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.653596

Abstract: miRNA-21 is a single-stranded non-coding RNA that is highly expressed in a variety of tumor cells. It participates in tumor cell proliferation, metabolism, metastasis, and drug resistance. Here, we tested the potential mechanism of miRNA-21… read more here.

Keywords: ddp; cisplatin; a549 ddp; ddp cells ... See more keywords
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PRDM14 mediates chemosensitivity and glycolysis in drug-resistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells

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recommendations! Published in 2021 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2020.11788

Abstract: Recent studies have reported that aberrant PR domain zinc finger protein 14 (PRDM14) expression is associated with the therapeutic sensitivity of cancer cells to drugs. However, its role in lung adenocarcinoma (LUAD) remains unclear. The… read more here.

Keywords: glycolysis; a549; a549 ddp; prdm14 ... See more keywords
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Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors

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recommendations! Published in 2018 at "Oncology Letters"

DOI: 10.3892/ol.2018.7849

Abstract: Multidrug resistance (MDR) is an obstacle for cancer chemotherapy. It was reported that 20(S)-ginsenoside Rg3 (hereafter Rg3) was able to regulate MDR in mouse leukemia cells. The present study investigated the effect of Rg3 on… read more here.

Keywords: rg3; a549 ddp; ddp; ddp xenograft ... See more keywords
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Polyphyllin I and VII potentiate the chemosensitivity of A549/DDP cells to cisplatin by enhancing apoptosis, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis

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recommendations! Published in 2019 at "Oncology Letters"

DOI: 10.3892/ol.2019.10895

Abstract: Poor response and resistance to cisplatin (DDP)-based chemotherapy frequently leads to treatment failure in advanced non-small cell lung cancer (NSCLC). The underlying molecular mechanism is extremely complex and currently remains unclear. The overexpression of cancerous… read more here.

Keywords: ddp; ppi ppvii; a549 ddp; ddp cells ... See more keywords
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Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer.

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recommendations! Published in 2019 at "Oncology reports"

DOI: 10.3892/or.2018.6861

Abstract: The roles of glutathione S‑transferase pi 1 (GSTP1), glutathione S‑transferase mu 2 (GSTM2) and glutathione S‑transferase alpha 1 (GSTA1) in cisplatin (DDP)‑resistance of solid cancer cells (A549/DDP, SKOV3/DDP and SGC7901/DDP) were compared following expression downregulation… read more here.

Keywords: ddp; sgc7901 ddp; skov3 ddp; a549 ddp ... See more keywords