A nonstructural 2B protein of enterovirus A71 increases cytosolic Ca2+ and induces apoptosis in human neuroblastoma SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of NeuroVirology"
DOI: 10.1007/s13365-019-00824-0
Abstract: Enterovirus A71 (EV-A71) is one of the causative agents causing the hand-foot-mouth disease which associated with fatal neurological complications. Several sporadic outbreaks of EV-A71 infections have been recently reported from Asia-Pacific regions and potentially established… read more here.
Keywords: protein; caspase; cytosolic ca2; a71 ... See more keywords
Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105683
Abstract: Enterovirus A71 (EV-A71), one of the major pathogens that causes hand, foot and mouth disease (HFMD), has seriously threatened the health and safety of young children. In this study, aminothiazole derivatives were synthesized and screened… read more here.
Keywords: aminothiazole derivatives; a71; enterovirus a71; a71 capsid ... See more keywords
Kinetics of the neutralising antibody response in patients with hand, foot, and mouth disease caused by EV-A71: A longitudinal cohort study in Zhengzhou during 2017-2019
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103398
Abstract: Background Hand, foot, and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) poses a serious threat to children's health. Kinetics of the neutralising antibody (NAb) response in EV-A71 infected HFMD patients remains unclear. The ideal… read more here.
Keywords: response; foot mouth; serum; hand foot ... See more keywords
VP1 residues around the five-fold axis of enterovirus A71 mediate heparan sulfate interaction.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2016.11.009
Abstract: Enterovirus A71 (EV-A71) is a neurotropic enterovirus that uses heparan sulfate as an attachment receptor. The molecular determinants of EV-A71-heparan sulfate interaction are unknown. With In silico heparin docking and mutagenesis of all possible lysine… read more here.
Keywords: heparin; enterovirus; heparan sulfate; interaction ... See more keywords
Antiviral effect in association with anti-apoptosis and anti-autophagy of repurposing formoterol fumarate dihydrate on enterovirus A71-infected neuronal cells.
Sign Up to like & getrecommendations! Published in 2022 at "Virus research"
DOI: 10.1016/j.virusres.2022.198692
Abstract: OBJECTIVE To investigate antiviral activity, anti-apoptosis and anti-autophagy associated with antiviral effect of repurposing formoterol fumarate dihydrate (FFD) against enterovirus A71 (EV-A71) infection in human neuroblastoma cells. METHODS In vitro antiviral effects of FFD against… read more here.
Keywords: apoptosis anti; apoptosis; anti apoptosis; a71 ... See more keywords
Temporal Proteomic and Phosphoproteomic Analysis of EV-A71-Infected Human Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00237
Abstract: Human enterovirus A71 (EV-A71), a member of the Picornaviridae family, is one of the main etiological viruses that lead to hand, foot, and mouth disease (HFMD). We utilized a multiplex tandem mass tag-based quantitative proteomic… read more here.
Keywords: phosphoproteomic analysis; analysis a71; a71; temporal proteomic ... See more keywords
Transcriptome of human neuroblastoma SH-SY5Y cells in response to 2B protein of enterovirus-A71
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05904-6
Abstract: Infection with enterovirus-A71 (EV-A71) can cause hand-foot-mouth disease associated with fatal neurological complications. The host response to EV-A71 has not yet been fully elucidated, thus, hampering the development of a precise therapeutic approach. A nonstructural… read more here.
Keywords: response; enterovirus a71; a71; protein ... See more keywords
Estimating the Severity Profile of Enterovirus A71 Infections in Children: A Bayesian Synthesis Framework
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Epidemiology"
DOI: 10.1093/aje/kwy238
Abstract: Enterovirus A71 (EV-A71) is responsible for the majority of severe cases of hand, foot, and mouth disease, but little evidence is available on the severity profile of EV-A71 infections. We formulated a hierarchical Bayesian model… read more here.
Keywords: enterovirus a71; severity profile; a71; a71 infections ... See more keywords
3,4-Dicaffeoylquinic Acid from the Medicinal Plant Ilex kaushue Disrupts the Interaction Between the Five-Fold Axis of Enterovirus A-71 and the Heparan Sulfate Receptor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00542-21
Abstract: The canyon region and the 5-fold axis of the EV-A71 viral particle located within the VP1 protein mediate the interaction of the virus with host surface receptors. The three most extensively investigated cellular receptors for… read more here.
Keywords: fold axis; a71; receptor; heparan sulfate ... See more keywords
Enterovirus A71 Promotes Exosome Secretion by the Nonstructural Protein 3A Interacting with Rab27a
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03446-22
Abstract: Research has shown that viral infection impacts exosome secretion, but its regulation mechanisms remain poorly understood. Nonstructural protein 3A of EV-A71 interacts with many host factors and is involved in the remodeling of cellular membranes.… read more here.
Keywords: exosome secretion; infection; secretion; nonstructural protein ... See more keywords
Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-019-0585-y
Abstract: BackgroundEnterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV-A71 were prevalent worldwide, including Taiwan, Malaysia, Singapore, Japan, and China. Between 2008 and 2011,… read more here.
Keywords: treatment; immunocompetent; mouse model; a71 ... See more keywords