The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1
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DOI: 10.1186/s12967-017-1131-x
Abstract: BackgroundLeflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, the molecular mechanism of the… read more here.
Keywords: 1726 treated; a77 1726; heme oxygenase; arthritis mice ... See more keywords