Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split‐washer‐type mechanism for substrate unfolding
Sign Up to like & getrecommendations! Published in 2019 at "Febs Letters"
DOI: 10.1002/1873-3468.13667
Abstract: Several pathologies have been associated with the AAA+ ATPase p97, an enzyme essential to protein homeostasis. Heterozygous polymorphisms in p97 have been shown to cause neurological disease, while elevated proteotoxic stress in tumours has made… read more here.
Keywords: mechanism; atpase p97; p97; aaa atpase ... See more keywords
Characterization and functional analysis of ERAD-related AAA+ ATPase Cdc48 in Aspergillus oryzae.
Sign Up to like & getrecommendations! Published in 2020 at "Fungal biology"
DOI: 10.1016/j.funbio.2020.06.004
Abstract: Aspergillus oryzae can secrete large amounts of enzymes. However, the production of abundant secretory proteins triggers the unfolded protein response (UPR) in the endoplasmic reticulum (ER), and it is not clear how ER-associated protein degradation… read more here.
Keywords: atpase cdc48; aaa atpase; aspergillus oryzae; erad ... See more keywords
The AAA+ ATPase p97 as a novel parasite and tuberculosis drug target.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in parasitology"
DOI: 10.1016/j.pt.2022.03.004
Abstract: The multifunctional AAA+ ATPase p97 is an unfoldase/segregase involved in various cellular processes and present in all kingdoms of life. In mammals and yeast, p97 functions upstream of the proteasome. Interestingly, proteasome inhibitors targeting pathogenic… read more here.
Keywords: aaa atpase; drug; atpase p97; drug target ... See more keywords
The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11194-w
Abstract: TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is an unusual AAA + ATPase that needs an external activator. Also, it likely does not thread a… read more here.
Keywords: per turn; torsina; subunits per; aaa atpase ... See more keywords
Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23854-x
Abstract: The hexameric AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis and initiates cytoplasmic maturation of the large ribosomal subunit by releasing the shuttling maturation factor Rlp24. Drg1 monomers contain two AAA-domains (D1 and… read more here.
Keywords: structural basis; inhibition; atpase drg1; drg1 ... See more keywords
Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208941120
Abstract: Significance Chaperones are key players in cellular homeostasis that can prevent potentially toxic protein misfolding and aggregation and allow stalled processes to resolve and continue. One of them is a AAA+ ATPase, p97, that acts… read more here.
Keywords: atpase p97; p97; adaptor; aaa atpase ... See more keywords
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj7615
Abstract: Researchers show how the antidepressant drug fluoxetine targets a viral protein and inhibits viral replication. read more here.
Keywords: site enterovirus; targets allosteric; allosteric site; fluoxetine targets ... See more keywords
Mitochondrial AAA‐ATPase Msp1 detects mislocalized tail‐anchored proteins through a dual‐recognition mechanism
Sign Up to like & getrecommendations! Published in 2019 at "EMBO reports"
DOI: 10.15252/embr.201846989
Abstract: The conserved AAA‐ATPase Msp1 is embedded in the outer mitochondrial membrane and removes mislocalized tail‐anchored (TA) proteins upon dysfunction of the guided entry of tail‐anchored (GET) pathway. It remains unclear how Msp1 recognizes its substrates.… read more here.
Keywords: atpase msp1; recognition; tail anchored; msp1 ... See more keywords
The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2017.00021
Abstract: The hexameric type II AAA ATPase (ATPase associated with various activities) p97 (also referred to as VCP, Cdc48, and Ter94) is critically involved in a variety of cellular activities including pathways such as DNA replication… read more here.
Keywords: post translational; p97; cofactor; aaa atpase ... See more keywords
Molecular Mechanisms Driving and Regulating the AAA+ ATPase VCP/p97, an Important Therapeutic Target for Treating Cancer, Neurological and Infectious Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050737
Abstract: p97/VCP, a highly conserved type II ATPase associated with diverse cellular activities (AAA+ ATPase), is an important therapeutic target in the treatment of neurodegenerative diseases and cancer. p97 performs a variety of functions in the… read more here.
Keywords: therapeutic target; p97; aaa atpase; atpase ... See more keywords