Toxic Activation of an AAA+ Protease by the Antibacterial Drug Cyclomarin A.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.05.008
Abstract: ATP-driven bacterial AAA+ proteases have been recognized as drug targets. They possess an AAA+ protein (e.g., ClpC), which threads substrate proteins into an associated peptidase (e.g., ClpP). ATPase activity and substrate selection of AAA+ proteins… read more here.
Keywords: cyma; aaa protease; cyclomarin; clpc ... See more keywords
Structural basis for distinct operational modes and protease activation in AAA+ protease Lon
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DOI: 10.1126/sciadv.aba8404
Abstract: Substrate-free and -bound states of Lon reveal distinct operational modes used by the enzyme to process protein substrates. Substrate-bound structures of AAA+ protein translocases reveal a conserved asymmetric spiral staircase architecture wherein a sequential ATP… read more here.
Keywords: operational modes; lon; aaa protease; distinct operational ... See more keywords
The plant i-AAA protease controls the turnover of an essential mitochondrial protein import component
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.200733
Abstract: ABSTRACT Mitochondria are multifunctional organelles that play a central role in energy metabolism. Owing to the life-essential functions of these organelles, mitochondrial content, quality and dynamics are tightly controlled. Across the species, highly conserved ATP-dependent… read more here.
Keywords: aaa protease; protease; plant; component ... See more keywords
Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis
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DOI: 10.3389/fmolb.2017.00044
Abstract: Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis.… read more here.
Keywords: bacillus subtilis; protease complexes; aaa protease; functional diversity ... See more keywords