AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.03.007
Abstract: Protein misfolding and overloaded proteostasis networks underlie a range of neurodegenerative diseases. No cures exist for these diseases, but developing effective therapeutic agents targeting the toxic, misfolded protein species in disease is one promising strategy. AAA+… read more here.
Keywords: protein; protein misfolding; neurodegenerative disease; aaa protein ... See more keywords
Characterizing ATP processing by the AAA+ protein p97 at the atomic level
Sign Up to like & getrecommendations! Published in 2024 at "Nature Chemistry"
DOI: 10.1038/s41557-024-01440-0
Abstract: The human enzyme p97 regulates various cellular pathways by unfolding hundreds of protein substrates in an ATP-dependent manner, making it an essential component of protein homeostasis and an impactful pharmacological target. The hexameric complex undergoes… read more here.
Keywords: spectroscopy; active site; protein; aaa protein ... See more keywords
Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad083
Abstract: Abstract Bacteriophage exclusion (‘BREX’) systems are multi-protein complexes encoded by a variety of bacteria and archaea that restrict phage by an unknown mechanism. One BREX factor, termed BrxL, has been noted to display sequence similarity… read more here.
Keywords: dna; activity; phage restriction; aaa protein ... See more keywords