The HSP90 inhibitor 17‐AAG induced calcium‐mediated apoptosis in filarial parasites
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.22003
Abstract: The available antifilarial medications are effective only against the larval stage of the filarial parasite. As a result, there is a pressing need for an adulticidal drug. The development of drugs requires the identification of… read more here.
Keywords: calcium; aag; aag induced; inhibitor ... See more keywords
Cooperative interaction between AAG and UV-DDB in the removal of modified bases
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1145
Abstract: Abstract UV-DDB is a DNA damage recognition protein recently discovered to participate in the removal of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxoG) by stimulating multiple steps of base excision repair (BER). In this study, we examined whether UV-DDB has… read more here.
Keywords: aag; cooperative interaction; ddb; aag ddb ... See more keywords
Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms
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DOI: 10.1371/journal.pone.0184619
Abstract: Alkylating agents are ubiquitous in our internal and external environments, causing DNA damage that contributes to mutations and cell death that can result in aging, tissue degeneration and cancer. Repair of methylated DNA bases occurs… read more here.
Keywords: death; cell death; alkylation; parp1 ... See more keywords
PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration
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DOI: 10.18632/oncotarget.19844
Abstract: Alkylating agents are commonly used to treat cancer. Although base excision repair (BER) is a major pathway for repairing DNA alkylation damage, under certain conditions, the initiation of BER produces toxic repair intermediates that damage… read more here.
Keywords: parp inhibitors; mice; alkylation induced; alkylation ... See more keywords
HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.796974
Abstract: Overactivated inflammation and catabolism induced by proinflammatory macrophages are involved in the pathological processes of intervertebral disc (IVD) degeneration (IVDD). Our previous study suggested the protective role of inhibiting heat shock protein 90 (HSP90) in… read more here.
Keywords: aag; catabolism induced; inflammation catabolism; hsp90 inhibitor ... See more keywords