Effects of rhein and Rheum palmatum L. extract on the pharmacokinetics and tissue distribution of aristolochic acid I and its demethylated metabolite in rats.
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DOI: 10.1016/j.jep.2020.113537
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Aristolochic acid nephropathy (AAN) is a kidney disease caused by the administration of plants containing aristolochic acids (AAs). Aristolochic acid I (AAI) is the main toxic component in AAs. Organic anion transporters (OATs)… read more here.
Keywords: tissue distribution; pharmacokinetics tissue; aai; aai aaia ... See more keywords