Periodic Variation of AAK1 in an Aβ1–42-Induced Mouse Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1085-3
Abstract: Inhibition of endocytosis in an Alzheimer’s disease (AD) model has been shown to be able to prevent amyloid β (Aβ)-induced damage and to exert a beneficial effect in treating AD. Adaptor-associated kinase 1 (AAK1), which… read more here.
Keywords: alzheimer disease; aak1; model; periodic variation ... See more keywords
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02132
Abstract: Recent mouse knockout studies identified adapter protein-2-associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. BMS-986176/LX-9211 (4), as a highly selective, CNS-penetrable, and potent AAK1 inhibitor, has advanced into phase II human… read more here.
Keywords: aak1; protein associated; associated kinase; neuropathic pain ... See more keywords
A patent review of adaptor associated kinase 1 (AAK1) inhibitors (2013-present)
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2021.1928637
Abstract: ABSTRACT Introduction Adaptor-associated kinase 1 (AAK1) has been proposed as being a promising drug target for the treatment of a variety of neurological and psychiatric disorders, such as schizophrenia, cognitive deficits in schizophrenia, Parkinson’s disease,… read more here.
Keywords: aak1 inhibitors; aak1; associated kinase; adaptor associated ... See more keywords