First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine
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DOI: 10.1055/s-0036-1588752
Abstract: A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in… read more here.
Keywords: total synthesis; first total; synthesis cytotoxic; aaptamine ... See more keywords