An examination of gastrointestinal absorption using the acetaminophen absorption test in critically ill patients with COVID‐19: A retrospective cohort study
Sign Up to like & getrecommendations! Published in 2021 at "Nutrition in Clinical Practice"
DOI: 10.1002/ncp.10687
Abstract: Abstract Objective Gastrointestinal (GI) dysfunction is prevalent in critically ill patients with coronavirus disease 2019 (COVID‐19). The acetaminophen absorption test (AAT) has been previously described as a direct method for assessment of GI function. Our… read more here.
Keywords: absorption; ill patients; aat; critically ill ... See more keywords
Necessity of examining the practical efficacy of phosphate binders
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DOI: 10.1007/s10157-021-02155-z
Abstract: Patients on maintenance hemodialysis (HD) generally require management of hyperphosphatemia and take phosphate binders (PBs) such as ferric citrate (FC) and lanthanum carbonate (LC) [1]. Meanwhile, many HD patients require antacid therapy (AAT). Although PBs… read more here.
Keywords: lc250; phosphate binders; aat; efficacy ... See more keywords
Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2018.03.012
Abstract: BACKGROUND & AIMS Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder causing pulmonary and liver disease. The PiZ mutation in AAT (SERPINA1) results in mis-folded AAT protein (Z-AAT) accumulating in hepatocytes, leading to fibrosis and… read more here.
Keywords: production; aat; alpha antitrypsin; arc aat ... See more keywords
Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation
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DOI: 10.1038/s41598-018-33851-8
Abstract: Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine proteases, which AAT inhibits, cleave… read more here.
Keywords: degranulation; pltp; kinase; aat ... See more keywords
Alpha1-antitrypsin protects lung cancer cells from staurosporine-induced apoptosis: the role of bacterial lipopolysaccharide
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DOI: 10.1038/s41598-020-66825-w
Abstract: Elevated levels of plasma alpha1-antitrypsin (AAT) correlate with a poor prognosis of various cancers. Herein, we investigated effects of exogenous AAT on non-small lung cancer cell lines with high (H1975) and very low (H661) baseline… read more here.
Keywords: apoptosis; induced apoptosis; aat; lung cancer ... See more keywords
Identification of an alpha-1 antitrypsin variant with enhanced specificity for factor XIa by phage display, bacterial expression, and combinatorial mutagenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-84618-7
Abstract: Coagulation Factor XIa (FXIa) is an emerging target for antithrombotic agent development. The M358R variant of the serpin alpha-1 antitrypsin (AAT) inhibits both FXIa and other proteases. Our aim was to enhance the specificity of… read more here.
Keywords: m358r; factor xia; phage; aat ... See more keywords
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20220055
Abstract: α1-antitrypsin (AAT) is a serine protease inhibitor synthesized in hepatocytes and protects the lung from damage by neutrophil elastase. AAT gene mutations result in AAT deficiency (AATD), which leads to lung and liver diseases. The… read more here.
Keywords: lman1 mcfd2; mcfd2; secretion; aat ... See more keywords
Safety of Intravenous Administration of an AAV8 Vector Coding for an Oxidation Resistant Human α1-antitrypsin for the Treatment of α1-antitrypsin Deficiency.
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DOI: 10.1089/hum.2022.192
Abstract: α1-antitrypsin (AAT) deficiency is a common autosomal recessive hereditary disorder, with a high risk for the development of early onset panacinar emphysema. AAT produced primarily in the liver, functions to protect the lung from neutrophil… read more here.
Keywords: aav8haat avl; antitrypsin; intravenous administration; study ... See more keywords
Withdrawal of anti-arrhythmic therapy after cavo-tricuspid isthmus ablation of typical atrial flutter
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DOI: 10.1093/europace/euab116.054
Abstract: Type of funding sources: None. Medical management of typical atrial flutter (AFL) is sometimes unsuccessful and may have adverse effects. Symptom control using radiofrequency cavo-tricuspid isthmus ablation (CTA) is a feasible alternative, given the fact… read more here.
Keywords: aat; withdrawal; ablation; anti arrhythmic ... See more keywords
Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiac004
Abstract: Rodent models of lipopolysaccharide (LPS)-induced pulmonary inflammation are used for anti-inflammatory drug testing. We aimed to characterize mice responses to aerosolized LPS alone or with intraperitoneal (i.p.) delivery of alpha1-antitrypsin (AAT). Balb/c mice were exposed… read more here.
Keywords: alpha1 antitrypsin; aerosolized lps; inflammatory; mice ... See more keywords
172: An Examination of Gastrointestinal Absorption in Critically Ill Patients With COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000726576.22276.14
Abstract: INTRODUCTION: Gastrointestinal (GI) dysfunction is prevalent in critically ill patients with coronavirus disease 2019 (COVID-19) Inadequate nutrition in critically ill patients has been associated with increased morbidity and mortality The acetaminophen absorption test (AAT) has… read more here.
Keywords: absorption; ill patients; aat; critically ill ... See more keywords