Human α‐synuclein overexpression upregulates SKOR1 in a rat model of simulated nigrostriatal ageing
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DOI: 10.1111/acel.14155
Abstract: Parkinson's disease (PD) is characterised by progressive loss of dopaminergic (DA) neurons from the substantia nigra (SN) and α‐synuclein (αSyn) accumulation. Age is the biggest risk factor for PD and may create a vulnerable pre‐parkinsonian… read more here.
Keywords: aav syn; syn; nigrostriatal ageing; model ... See more keywords
The Influence of Neurotrophic Factors BDNF and GDNF Overexpression on the Functional State of Mice and Their Adaptation to Audiogenic Seizures
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DOI: 10.3390/brainsci12081039
Abstract: The high prevalence of diagnosed cases of severe neurological disorders, a significant proportion of which are epilepsy, contributes to a high level of mortality and disability in the population. Neurotrophic factors BDNF and GNDF are… read more here.
Keywords: neurotrophic factors; aav syn; bdnf gdnf; viral constructs ... See more keywords