Systematic studies on stabilization of AAV vector formulations by lyophilization.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2022.03.004
Abstract: Adeno-associated virus (AAV) vectors have evolved as one of the most promising delivery systems for gene therapy. The current standard for AAV vector storage is deep-freezing below -60°C. While this allows for long-term vector storage… read more here.
Keywords: storage; systematic studies; aav vector; studies stabilization ... See more keywords
AAV vector-mediated in vivo reprogramming into pluripotency
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05059-x
Abstract: In vivo reprogramming of somatic cells into induced pluripotent stem cells (iPSC) holds vast potential for basic research and regenerative medicine. However, it remains hampered by a need for vectors to express reprogramming factors (Oct-3/4,… read more here.
Keywords: vivo reprogramming; vector; vector mediated; aav vector ... See more keywords
AAV vector distribution in the mouse respiratory tract following four different methods of administration
Sign Up to like & getrecommendations! Published in 2017 at "BMC Biotechnology"
DOI: 10.1186/s12896-017-0365-2
Abstract: BackgroundTargeted delivery of gene therapy vectors to the mouse respiratory tract is often performed via intranasal or intratracheal administration; however, there can be a great deal of variability between these methods, which could potentially influence… read more here.
Keywords: vector; administration; respiratory tract; mouse respiratory ... See more keywords
AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.870799
Abstract: In the last four decades, monoclonal antibodies and their derivatives have emerged as a powerful class of therapeutics, largely due to their exquisite targeting specificity. Several clinical areas, most notably oncology and autoimmune disorders, have… read more here.
Keywords: central nervous; nervous system; delivery; aav vector ... See more keywords
Evaluation of AAV-DJ vector for retinal gene therapy
Sign Up to like & getrecommendations! Published in 2019 at "PeerJ"
DOI: 10.7717/peerj.6317
Abstract: Purpose The most common virus vector used in gene therapy research for ophthalmologic diseases is the adeno-associated virus (AAV) vector, which has been used successfully in a number of preclinical and clinical studies. It is… read more here.
Keywords: aav; gene; aav vector; gene therapy ... See more keywords