Abatacept for treatment-refractory pediatric CTLA4-haploinsufficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical immunology"
DOI: 10.1016/j.clim.2021.108779
Abstract: CTLA4-haploinsufficiency is a complex disease of immune dysregulation presenting with a broad spectrum of clinical manifestations. CTLA4-Fc fusion proteins such as abatacept have been described to alleviate immune dysregulation in several adult cases of CTLA4-haploinsufficiency.… read more here.
Keywords: abatacept treatment; ctla4 haploinsufficiency; treatment refractory; haploinsufficiency ... See more keywords
Influence of abatacept treatment on oral wound healing: Experimetnal model on rats.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2019.117243
Abstract: The present study aimed to evaluate the healing process of ulcers in the jugal mucosa of Wistar rats treated with abatacept. The rats were randomly assigned to four groups: saline-treated control (0.3 ml / kg) abatacept-treated… read more here.
Keywords: influence abatacept; wound healing; abatacept treatment; treatment oral ... See more keywords
Long-term abatacept treatment for 48 weeks in patients with primary Sjögren's syndrome: The open-label extension phase of the ASAP-III trial.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2022.151955
Abstract: OBJECTIVE To investigate treatment efficacy of long-term abatacept treatment in pSS patients. METHODS The single-centre ASAP-III trial consisted of two phases: the randomised, double-blind, placebo-controlled phase (1:1 randomisation) from baseline to week 24, of which… read more here.
Keywords: abatacept treatment; iii trial; long term; treatment ... See more keywords
Effect of CTLA4‐Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12732
Abstract: We aimed to evaluate in vivo effects of abatacept on phenotypes of T and B cells in the circulation of myositis patients in a sub‐study of the ARTEMIS trial. Twelve patients with paired frozen PBMCs… read more here.
Keywords: abatacept treatment; effect ctla4; treatment; peripheral blood ... See more keywords
Abatacept for the treatment of adults with psoriatic arthritis: patient selection and perspectives
Sign Up to like & getrecommendations! Published in 2018 at "Psoriasis: Targets and Therapy"
DOI: 10.2147/ptt.s146076
Abstract: Psoriatic arthritis (PsA) is a heterogeneous disease with several clinical subtypes including peripheral arthritis, dactylitis, enthesitis, nail disease, and axial arthritis. Nonsteroidal anti-inflammatory drugs, glucocorticoids, and conventional disease-modifying agents are used as first line in… read more here.
Keywords: psoriatic arthritis; psa; abatacept treatment; treatment ... See more keywords
Immunomodulatory mechanisms of abatacept: A therapeutic strategy for COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.951115
Abstract: Coronavirus disease 2019 (COVID-19) caused by coronavirus-2 (SARS-CoV-2) infection has rapidly spread throughout the world and become a major threat to human beings. Cytokine storm is a major cause of death in severe patients. Abatacept… read more here.
Keywords: abatacept treatment; covid; treatment; cov infection ... See more keywords