Self-immunity to antibacterial peptides by ABC transporters.
Sign Up to like & getrecommendations! Published in 2020 at "FEBS letters"
DOI: 10.1002/1873-3468.13953
Abstract: Bacteria produce under certain stress conditions bacteriocins and microcins that display antibacterial activity against closely related species for survival. Bacteriocins and microcins exert their antibacterial activity by either disrupting the membrane or inhibiting essential intracellular… read more here.
Keywords: abc transporters; bacteriocins microcins; immunity; antibacterial peptides ... See more keywords
Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin
Sign Up to like & getrecommendations! Published in 2020 at "Febs Letters"
DOI: 10.1002/1873-3468.13982
Abstract: ABC transporters (ATP‐binding cassette transporter) traffic drugs and their metabolites across membranes, making ABC transporter expression levels a key factor regulating local drug concentrations in different tissues and individuals. Yet, quantification of ABC transporters remains… read more here.
Keywords: abc transporters; mass spectrometry; abundance; brain ... See more keywords
Two ABC transporters are differentially involved in the toxicity of two Bacillus thuringiensis Cry1 toxins to the invasive crop-pest Spodoptera frugiperda (J. E. Smith).
Sign Up to like & getrecommendations! Published in 2020 at "Pest management science"
DOI: 10.1002/ps.6170
Abstract: BACKGROUND The fall armyworm Spodoptera frugiperda is a major agricultural pest that has invaded the East Hemisphere since 2016, generating a serious threat to the food security worldwide including Africa and Asia. The Cry toxins… read more here.
Keywords: abc transporters; spodoptera frugiperda; sfabcc2 sfabcc3; sfabcc2 ... See more keywords
ATP-binding cassette (ABC) transporters in caprine preantral follicles: gene and protein expression
Sign Up to like & getrecommendations! Published in 2018 at "Cell and Tissue Research"
DOI: 10.1007/s00441-018-2804-3
Abstract: The multidrug resistance proteins ABCB1, ABCC2 and ABCG2 are an energy-dependent efflux pump that functions in systemic detoxification processes. Physiologically expressed in a variety of tissues, most abundantly in the liver and intestinal epithelia, placenta,… read more here.
Keywords: protein expression; abc transporters; preantral follicles; abcb1 abcc2 ... See more keywords
Mitochondrial membrane transporters and metabolic switch in heart failure
Sign Up to like & getrecommendations! Published in 2018 at "Heart Failure Reviews"
DOI: 10.1007/s10741-018-9756-2
Abstract: Mitochondrial dysfunction is widely recognized as a major factor for the progression of cardiac failure. Mitochondrial uptake of metabolic substrates and their utilization for ATP synthesis, electron transport chain activity, reactive oxygen species levels, ion… read more here.
Keywords: abc transporters; heart; metabolic switch; heart failure ... See more keywords
The Interplay of ABC Transporters in Aβ Translocation and Cholesterol Metabolism: Implicating Their Roles in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02211-x
Abstract: The occurrence of Alzheimer's disease (AD) worldwide has been progressively accelerating at an alarming rate, without any successful therapeutic strategy for the disease mitigation. The complexity of AD pathogenesis needs to be targeted with an… read more here.
Keywords: cholesterol metabolism; alzheimer disease; abc transporters; disease ... See more keywords
Substrate and method dependent inhibition of three ABC‐transporters (MDR1, BCRP, and MRP2)
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.03.002
Abstract: ABSTRACT Drug transport and drug‐drug interactions (DDI) with human ABC transporters are generally investigated in mammalian cell lines or inverted membrane vesicles from insect cells (Sf9) overexpressing the transporter of interest. In this study, we… read more here.
Keywords: abc transporters; mrp2; inhibition; probe substrates ... See more keywords
Altered Gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental pollution"
DOI: 10.1016/j.envpol.2018.10.092
Abstract: Adenosine triphosphate-binding cassette (ABC) transporters, including P-glycoprotein (Pgp) and multi-resistance associated proteins (Mrps), have been considered important participants in the self-protection of zebrafish embryos against environmental pollutants, but their possible involvement in the efflux and… read more here.
Keywords: abc transporters; nuclear receptors; receptors oxidative; zebrafish embryos ... See more keywords
Transcriptional plasticity of different ABC transporter genes from Tribolium castaneum contributes to diflubenzuron resistance.
Sign Up to like & getrecommendations! Published in 2019 at "Insect biochemistry and molecular biology"
DOI: 10.1016/j.ibmb.2019.103282
Abstract: The development of insecticide resistance challenges the sustainability of pest control and several studies have shown that ABC transporters contribute to this process. ABC transporters are known to transport a large range of chemically diverse… read more here.
Keywords: abc transporters; abc; tribolium castaneum; resistance ... See more keywords
Functional characterization of two ABC transporters in Sinonovacula constricta gills and their barrier action in response to pathogen infection.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.10.047
Abstract: P-glycoprotein (P-gp or ABCB1) and multidrug resistance associated proteins (MRPs or ABCC) belonging to the family of ATP-binding cassette (ABC) transporters protect aquatic organisms from various toxicants and pathogen exposure. The function of ABC transporters… read more here.
Keywords: abc transporters; pathogen; response; constricta ... See more keywords
The expected characteristics of an in vitro human Blood Brain Barrier model derived from cell lines, for studying how ABC transporters influence drug permeability
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.03.002
Abstract: Abstract The interface between the Central Nervous System (CNS) and the blood, known as the Blood Brain Barrier (BBB), must possess highly effective mechanisms for facilitating the transport of specific nutrients and limiting the transport… read more here.
Keywords: abc transporters; drug; permeability; model ... See more keywords