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   Articles with "abca1 abcg1" as a keyword



Lupus nephritis: Cholesterol accumulation in DCs promotes autoimmunity

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recommendations! Published in 2017 at "Nature Reviews Nephrology"

DOI: 10.1038/nrneph.2017.72

Abstract: Cholesterol accumulation in dendritic cells (DCs) activates inflammatory signalling pathways that promote autoimmunity. This new finding from Marit Westerterp and colleagues suggests that suppression of DC cholesterol efflux pathways might have a role in the… read more here.

Keywords: dcs; cholesterol accumulation; cholesterol; abca1 abcg1 ... See more keywords

Deficiency of Abca1 and Abcg1 mediated cholesterol efflux pathways in smooth muscle cells enhances vasoconstriction but does not affect atherosclerosis

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recommendations! Published in 2024 at "Cardiovascular Research"

DOI: 10.1093/cvr/cvae088.152

Abstract: Funding Acknowledgements  Type of funding sources: Public grant(s) – National budget only. Main funding source(s): VIDI grant from Netherlands Organization of Scientific Research (NWO). Rosalind Franklin Fellowship from the University Medical Center Groningen. Both to… read more here.

Keywords: cholesterol efflux; abca1 abcg1; deficiency; cholesterol ... See more keywords

Abstract 4119262: Anti-atherosclerotic Potential of M2 Macrophage-Derived Exosomes by Promoting Cholesterol Efflux of Foam Cell-Like Vascular Smooth Muscle Cells via the PPARγ-LXRα-ABCA1/ ABCG1 Pathway

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recommendations! Published in 2024 at "Circulation"

DOI: 10.1161/circ.150.suppl_1.4119262

Abstract: Background: Impediment in the excretion of lipid deposits within SMC-derived foam cells (SMC-FCs) is one of the reasons for the continuous expansion of the plaque necrotic core. This study aims to explore the effect and… read more here.

Keywords: smc fcs; abca1; cholesterol efflux; abca1 abcg1 ... See more keywords

ABCA1 and ABCG1 cholesterol transporters expression on metastatic renal cell carcinoma: Impact on immunotherapy outcomes (CHOMET study).

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recommendations! Published in 2025 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2025.43.5_suppl.568

Abstract: 568 Background: Although immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, most patients do not achieve benefits, emphasizing the need to understand the mechanisms of resistance. Previous analysis highlighted the association between blood cholesterol levels,… read more here.

Keywords: intensity expression; cell; abca1 abcg1; expression ... See more keywords

Enhancement of ABCA1 and ABCG1 Expression and Cholesterol Efflux by a Metabolite of Tipelukast: A Potential Therapeutic Strategy for Atherosclerosis.

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recommendations! Published in 2025 at "Journal of atherosclerosis and thrombosis"

DOI: 10.5551/jat.65669

Abstract: Aims: MN-001 (tipelukast), a compound with lipid-modulating and anti-inflammatory properties, and its active metabolite MN-002, have been suggested to influence cholesterol metabolism. This study aimed to investigate whether MN-001 and MN-002 enhance cholesterol efflux via… read more here.

Keywords: abca1 abcg1; abcg1 expression; cholesterol efflux; cholesterol ... See more keywords