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   Articles with "abca7" as a keyword



The role of ABCA7 in Alzheimer’s disease: evidence from genomics, transcriptomics and methylomics

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recommendations! Published in 2019 at "Acta Neuropathologica"

DOI: 10.1007/s00401-019-01994-1

Abstract: Genome-wide association studies (GWAS) originally identified ATP-binding cassette, sub-family A, member 7 (ABCA7), as a novel risk gene of Alzheimer’s disease (AD). Since then, accumulating evidence from in vitro, in vivo, and human-based studies has… read more here.

Keywords: alzheimer disease; disease; abca7; evidence ... See more keywords

ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep40273

Abstract: ABCA7 is an ABC transporter expressed on the plasma membrane, and actively exports phospholipid complexes from the cytoplasmic to the exocytoplasmic leaflet of membranes. Invariant NKT (iNKT) cells are a subpopulation of T lymphocytes that… read more here.

Keywords: raft content; abca7 regulates; abca7; nkt cell ... See more keywords

Analysis of Genetic Association Between ABCA7 Polymorphism and Alzheimer’s Disease Risk in the Southern Chinese Population

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recommendations! Published in 2022 at "Frontiers in Aging Neuroscience"

DOI: 10.3389/fnagi.2022.819499

Abstract: Objective The study aimed to clarify the association of the 21 single nucleotide polymorphisms (SNPs) with Alzheimer’s disease (AD) in the population of southern China. Methods A case-control study was conducted with a total sample… read more here.

Keywords: abca7; alzheimer disease; risk; association ... See more keywords

ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation

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recommendations! Published in 2021 at "Frontiers in Neuroscience"

DOI: 10.3389/fnins.2021.647974

Abstract: The ATP binding cassette subfamily A member 7 (ABCA7) gene is one of the significant susceptibility loci for Alzheimer’s disease (AD). Furthermore, ABCA7 loss of function variants resulting from premature termination codon in the gene… read more here.

Keywords: acid metabolism; metabolism; fatty acid; inflammation ... See more keywords