Clinical utility of ABCB1 genotyping for preventing toxicity in treatment with irinotecan
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.08.026
Abstract: ABSTRACT Preventing severe irinotecan‐induced adverse reactions would allow us to offer better treatment and improve patients’ quality of life. Transporters, metabolizing enzymes, and genes involved in the folate pathway have been associated with irinotecan‐induced toxicity.… read more here.
Keywords: treatment; adverse reactions; overall toxicity; toxicity ... See more keywords
Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00457
Abstract: ATP-binding cassette (ABC) transporters, which are concerned with the efflux of anticancer drugs from cancer cells, have a pivotal role in multidrug resistance (MDR). In particular, ABCB1 is a well-known ABC transporter that develops MDR… read more here.
Keywords: resistance; phenethylisoquinoline alkaloid; cancer; abcb1 ... See more keywords
In Vitro Screening and MD Simulations of Thiourea Derivatives against SARS-CoV-2 in Association with Multidrug Resistance ABCB1 Transporter
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c04671
Abstract: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is considered a global public health concern since it causes high morbidity and mortality. Recently, it has been reported that repurposed anti-COVID-19 drugs might interact with multidrug… read more here.
Keywords: multidrug resistance; transporter; thiourea derivatives; abcb1 ... See more keywords
MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-79144-x
Abstract: The efficacy of aminolevulinic acid (5-ALA)-based photodynamic diagnosis (5-ALA-PDD) and photodynamic therapy (5-ALA-PDT) is dependent on 5-ALA-induced cancer-specific accumulation of protoporphyrin IX (PpIX). We previously reported that inhibition of oncogenic Ras/MEK increases PpIX accumulation in… read more here.
Keywords: fech; ppix accumulation; accumulation; abcb1 ... See more keywords
Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics
Sign Up to like & getrecommendations! Published in 2019 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.119.087684
Abstract: Maraviroc is a chemokine receptor 5 (CCR5) inhibitor used in the treatment of human immunodeficiency virus (HIV) that also shows therapeutic potential for several autoimmune, cancer, and inflammatory diseases that can afflict pregnant women. However,… read more here.
Keywords: maraviroc; abcg2 abcc2; maraviroc abcb1; abcb1 ... See more keywords
Abstract P5-06-30: Identification of novel single nucleotide polymorphisms located in MAP3K1 and ABCB1 genes as markers for poor overall survival in early-stage hormone receptor-positive breast cancer using next-generation sequencing
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs19-p5-06-30
Abstract: Background: We previously revealed that single nucleotide polymorphisms (SNPs) of CYP19A1, MAP3K1 rs889312, and ABCB1 rs2032582 were associated with overall survival (OS) in early-stage hormone receptor (HR)-positive breast cancer patients. Previous studies also showed that… read more here.
Keywords: snps; breast cancer; abcb1; cancer ... See more keywords
Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000487578
Abstract: Background/Aims: The overexpression of ATP-Binding Cassette (ABC) transporters has known to be one of the major obstacles impeding the success of chemotherapy in drug resistant cancers. In this study, we evaluated voruciclib, a CDK 4/6… read more here.
Keywords: drug; cancer; abcb1 abcg2; abcb1 ... See more keywords
Effect of CYP3 A4, CYP3 A5 and ABCB1 gene polymorphisms on the clinical efficacy of tacrolimus in the treatment of nephrotic syndrome
Sign Up to like & getrecommendations! Published in 2018 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-018-0202-9
Abstract: BackgroundThe efficacy of tacrolimus (TAC) is variable in the treatment of nephrotic syndrome (NS), which might be related to genetic variation among patients. Therefore, we aim to investigate the effects of CYP3 A4, CYP3 A5… read more here.
Keywords: clinical efficacy; gene polymorphisms; efficacy; cyp3 ... See more keywords
Use of photoimmunoconjugates to characterize ABCB1 in cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Nanophotonics"
DOI: 10.1515/nanoph-2021-0252
Abstract: Abstract Accurate detection of ATP-binding cassette drug transporter ABCB1 expression is imperative for precise identification of drug-resistant tumors. Existing detection methods fail to provide the necessary molecular details regarding the functional state of the transporter.… read more here.
Keywords: cancer cells; bpd; uic2 bpd; abcb1 ... See more keywords
Pharmacogenetic Approach to Toxicity in Breast Cancer Patients Treated with Taxanes.
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DOI: 10.21873/anticanres.11610
Abstract: BACKGROUND Taxanes are widely used to treat breast cancer patients. Taxanes are metabolized in human liver by the cytochrome CYP3A and are substrate of ATP-binding cassette multidrug transporters ABCB1. Single-nucleotide polymorphisms (SNPs) in genes involved… read more here.
Keywords: breast; breast cancer; toxicity; abcb1 ... See more keywords
Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.2210/pdb6fn4/pdb
Abstract: The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter that has a key role in protecting tissues from toxic insult and contributes to multidrug extrusion from cancer cells. Here, we report the near-atomic resolution… read more here.
Keywords: zosuquidar uic2; structure zosuquidar; structure; abcb1 ... See more keywords