Articles with "abcb1 gene" as a keyword



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Association of ABCB1 gene polymorphism (C1236T and C3435T) with refractory epilepsy in Iraqi patients

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Published in 2020 at "Molecular Biology Reports"

DOI: 10.1007/s11033-020-05540-1

Abstract: The mechanisms of refractory epilepsy (RE) are most likely multifactorial, involving environmental, genetic, as well as disease- and drug-related factors. We aimed to study is to investigate the possible association of two ABCB1 gene polymorphism… read more here.

Keywords: epilepsy; abcb1 gene; polymorphism; refractory epilepsy ... See more keywords
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The effect of Gender and ABCB1 Gene Polymorphism on the Pharmacokinetics of Azithromycin in Healthy Male and Female Pakistani Subjects.

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Published in 2020 at "Canadian journal of physiology and pharmacology"

DOI: 10.1139/cjpp-2019-0569

Abstract: BACKGROUND In the current study, the possible outcome of sex difference and genotypic polymorphism of ABCB1 gene encoding p-glycoprotein (involved in biliary excretion of azithromycin) on the pharmacokinetics of azithromycin has been evaluated. METHODS An… read more here.

Keywords: male female; pharmacokinetics azithromycin; abcb1 gene; pakistani ... See more keywords
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Fast and simple detection methods for the 4–base pair deletion of canine MDR1/ABCB1 gene by PCR and isothermal amplification

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Published in 2017 at "Journal of Veterinary Diagnostic Investigation"

DOI: 10.1177/1040638716683213

Abstract: Dogs with a 4-bp deletion in the MDR1 (or ABCB1) gene show intolerance to certain drugs routinely used in veterinary medicine, such as ivermectin, vincristine, and doxorubicin. The mutation leads to a dysfunctional P-glycoprotein drug… read more here.

Keywords: mdr1 abcb1; isothermal amplification; deletion; abcb1 gene ... See more keywords

High expression levels and the C3435T SNP of the ABCB1 gene are associated with lower survival in adult patients with acute myeloblastic leukemia in Mexico City

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Published in 2021 at "BMC Medical Genomics"

DOI: 10.1186/s12920-021-01101-y

Abstract: Background Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by different genetic alterations that cause changes in the normal mechanisms of differentiation, which are associated with chemoresistance. The ABCB1 gene is part of… read more here.

Keywords: abcb1 gene; c3435t snp; survival; expression levels ... See more keywords
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Effect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance gene

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Published in 2018 at "Journal of Translational Medicine"

DOI: 10.1186/s12967-018-1620-6

Abstract: BackgroundIn acute lymphoblastic leukemia (ALL), high ABCB1 gene expression has been associated with treatment resistance, which affects patient prognosis. Many preclinical reports and retrospective population studies have shown an anti-cancer effect of metformin. Therefore, the… read more here.

Keywords: metformin; gene expression; abcb1 gene; expression ... See more keywords