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Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05540-1
Abstract: The mechanisms of refractory epilepsy (RE) are most likely multifactorial, involving environmental, genetic, as well as disease- and drug-related factors. We aimed to study is to investigate the possible association of two ABCB1 gene polymorphism…
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Keywords:
epilepsy;
abcb1 gene;
polymorphism;
refractory epilepsy ... See more keywords
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Published in 2020 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2019-0569
Abstract: BACKGROUND In the current study, the possible outcome of sex difference and genotypic polymorphism of ABCB1 gene encoding p-glycoprotein (involved in biliary excretion of azithromycin) on the pharmacokinetics of azithromycin has been evaluated. METHODS An…
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Keywords:
male female;
pharmacokinetics azithromycin;
abcb1 gene;
pakistani ... See more keywords
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Published in 2017 at "Journal of Veterinary Diagnostic Investigation"
DOI: 10.1177/1040638716683213
Abstract: Dogs with a 4-bp deletion in the MDR1 (or ABCB1) gene show intolerance to certain drugs routinely used in veterinary medicine, such as ivermectin, vincristine, and doxorubicin. The mutation leads to a dysfunctional P-glycoprotein drug…
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Keywords:
mdr1 abcb1;
isothermal amplification;
deletion;
abcb1 gene ... See more keywords
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Published in 2021 at "BMC Medical Genomics"
DOI: 10.1186/s12920-021-01101-y
Abstract: Background Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by different genetic alterations that cause changes in the normal mechanisms of differentiation, which are associated with chemoresistance. The ABCB1 gene is part of…
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Keywords:
abcb1 gene;
c3435t snp;
survival;
expression levels ... See more keywords
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Published in 2018 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-018-1620-6
Abstract: BackgroundIn acute lymphoblastic leukemia (ALL), high ABCB1 gene expression has been associated with treatment resistance, which affects patient prognosis. Many preclinical reports and retrospective population studies have shown an anti-cancer effect of metformin. Therefore, the…
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Keywords:
metformin;
gene expression;
abcb1 gene;
expression ... See more keywords