Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells
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DOI: 10.1080/14756366.2022.2127700
Abstract: Abstract Multidrug resistance (MDR) is a leading cause for treatment failure in cancer patients. One of the reasons of MDR is drug efflux by ATP-binding cassette (ABC) transporters in eukaryotic cells especially ABCB1 (P-glycoprotein). In… read more here.
Keywords: cancer cells; novel trisubstituted; multidrug resistance; trisubstituted benzimidazole ... See more keywords