Wnt/IL‐1β/IL‐8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5
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DOI: 10.1002/ijc.32419
Abstract: Malignant pleural mesothelioma (MPM) is a tumor with high chemoresistance and poor prognosis. MPM‐initiating cells (ICs) are known to be drug resistant, but it is unknown if and how stemness‐related pathways determine chemoresistance. Moreover, there… read more here.
Keywords: mpm; chemoresistance; mesothelioma; abcb5 ... See more keywords
STAT1 upregulates glutaminase and modulates amino acids and glutathione metabolism.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.006
Abstract: We previously reported the upregulation of cellular Glu and glutathione levels in human ABCB5- and murine Abcb5-transfected cells. Here, we demonstrate the upregulation of STAT1 and glutaminase (GLS) in ABCB5/Abcb5-transfected cells. Among a total of… read more here.
Keywords: abcb5; high expressing; stat1; resistance ... See more keywords
Ex vivo-expanded highly pure ABCB5+ mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data
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DOI: 10.1016/j.jcyt.2020.08.012
Abstract: Background aim: Mesenchymal stromal cells (MSCs) hold promise for the treatment of tissue damage and injury. However, MSCs comprise multiple subpopulations with diverse properties, which could explain inconsistent therapeutic outcomes seen among therapeutic attempts. Recently,… read more here.
Keywords: mesenchymal stromal; abcb5; product; process ... See more keywords
Genetic variation in ABCB5 associates with risk of hepatocellular carcinoma
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DOI: 10.1111/jcmm.15691
Abstract: Expression of ATP‐binding cassette B5 (ABCB5) has been demonstrated to confer chemoresistance, enhance cancer stem cell properties and associate with poor prognosis in hepatocellular carcinoma (HCC). The aim of this study was to evaluate the… read more here.
Keywords: hepatocellular carcinoma; hcc; abcb5; blood ... See more keywords
Clinical trial of ABCB5-positive mesenchymal stem cells for recessive dystrophic epidermolysis bullosa.
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DOI: 10.1172/jci.insight.151922
Abstract: BACKGROUND Recessive dystrophic epidermolysis bullosa (RDEB) is a rare, devastating, and life-threatening inherited skin fragility disorder due to a lack of functional type VII collagen, for which no effective therapy exists. ABCB5-positive dermal mesenchymal stem… read more here.
Keywords: abcb5; epidermolysis bullosa; trial; recessive dystrophic ... See more keywords