In Vitro Transport Activity and Trafficking of MRP2/ABCC2 Polymorphic Variants
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2160-0
Abstract: PurposeMultidrug resistance-associated protein 2 (MRP2/ABCC2) is an efflux pump that removes drugs and chemicals from cells. We sought to characterize the expression, trafficking and in vitro activity of seven single nucleotide polymorphisms (SNPs) in the… read more here.
Keywords: abcc2; mrp2; transport; mrp2 abcc2 ... See more keywords
Role of ERK1/2 in TNFα-induced internalization of Abcc2 in rat hepatocyte couplets.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.04.024
Abstract: TNFα is a cytokine whose levels are increased in inflammatory pathologies that are associated with cholestasis. Endocytic internalization of Abcc2 (multidrug resistance-associated protein 2), a canalicular transporter of organic anions that is implicated in the… read more here.
Keywords: internalization abcc2; abcc2; internalization; tnf induced ... See more keywords
Clinical Relevance of ABCB1, ABCG2, and ABCC2 Gene Polymorphisms in Chronic Myeloid Leukemia Patients Treated With Nilotinib
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.672287
Abstract: Tyrosine kinase inhibitors (TKIs) have radically changed the outcome of chronic myeloid leukemia (CML) patients in the last 20 years. Moreover, the advent of second generation TKIs, namely nilotinib and dasatinib, have largely increased the… read more here.
Keywords: abcc2; patients treated; chronic myeloid; treated nilotinib ... See more keywords
The Cadherin Cry1Ac Binding-Region is Necessary for the Cooperative Effect with ABCC2 Transporter Enhancing Insecticidal Activity of Bacillus thuringiensis Cry1Ac Toxin
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DOI: 10.3390/toxins11090538
Abstract: Bacillus thuringiensis Cry1Ac toxin binds to midgut proteins, as cadherin (CAD) and ABCC2 transporter, to form pores leading to larval death. In cell lines, co-expression of CAD and ABCC2 enhance Cry1Ac toxicity significantly, but the… read more here.
Keywords: abcc2; cry1ac toxicity; gfp; cry1ac ... See more keywords