Therapeutic drugs modulate ATP-Binding cassette transporter-mediated transport of amyloid beta(1-42) in brain microvascular endothelial cells.
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DOI: 10.1016/j.ejphar.2020.173009
Abstract: Deposition of amyloid-β peptide (Aβ(1-42)) is a hallmark of Alzheimer's disease. Clearance of Aβ(1-42), across the blood-brain barrier (BBB), is mediated by ATP-binding Cassette (ABC) efflux transporters. Many therapeutic drugs inhibit ABC transporters, but little… read more here.
Keywords: abcb1 abcc5; transport; abcc5 abcg2; endothelial cells ... See more keywords