ABCC6 plays a significant role in the transport of nilotinib and dasatinib, and contributes to TKI resistance in vitro, in both cell lines and primary patient mononuclear cells
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DOI: 10.1371/journal.pone.0192180
Abstract: ATP Binding Cassette family efflux proteins ABCB1 and ABCG2 have previously been demonstrated to interact with Tyrosine Kinase Inhibitors (TKIs); however, evidence for the interaction of other potentially relevant drug transporters with TKIs is lacking.… read more here.
Keywords: abcc6; cell lines; transport; nilotinib dasatinib ... See more keywords
Abcc6 Null Mice—a Model for Mineralization Disorder PXE Shows Vertebral Osteopenia Without Enhanced Intervertebral Disc Calcification With Aging
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DOI: 10.3389/fcell.2022.823249
Abstract: Chronic low back pain is a highly prevalent health condition intricately linked to intervertebral disc degeneration. One of the prominent features of disc degeneration that is commonly observed with aging is dystrophic calcification. ATP-binding cassette… read more here.
Keywords: abcc6; bone; intervertebral disc; pxe ... See more keywords
Targeting ABCC6 in Mesenchymal Stem Cells: Impairment of Mature Adipocyte Lipid Homeostasis
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DOI: 10.3390/ijms23169218
Abstract: Mutations in ABCC6, an ATP-binding cassette transporter with a so far unknown substrate mainly expressed in the liver and kidney, cause pseudoxanthoma elasticum (PXE). Symptoms of PXE in patients originate from the calcification of elastic… read more here.
Keywords: abcc6; lipid homeostasis; stem cells; mature ... See more keywords