Transmembrane Domain Single-Nucleotide Polymorphisms Impair Expression and Transport Activity of ABC Transporter ABCG2
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2127-1
Abstract: PurposeTo study the function and expression of nine naturally occurring single-nucleotide polymorphisms (G406R, F431L, S441N, P480L, F489L, M515R, L525R, A528T and T542A) that are predicted to reside in the transmembrane regions of the ABC transporter… read more here.
Keywords: single nucleotide; transport; expression; abcg2 ... See more keywords
Role of the Abcg2 transporter in plasma levels and tissue accumulation of the anti-inflammatory tolfenamic acid in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109537
Abstract: The Breast Cancer Resistance Protein (BCRP/ABCG2) is an ATP-binding cassette efflux transporter that is expressed in the apical membrane of cells from relevant tissues involved in drug pharmacokinetics such as liver, intestine, kidney, testis, brain… read more here.
Keywords: plasma; acid; tolfenamic acid; mice ... See more keywords
A new porphyrin as selective substrate-based inhibitor of breast cancer resistance protein (BCRP/ABCG2).
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109718
Abstract: The ABCG2 transporter plays a pivotal role in multidrug resistance, however, no clinical trial using specific ABCG2 inhibitors have been successful. Although ABC transporters actively extrude a wide variety of substrates, photodynamic therapeutic agents with… read more here.
Keywords: protein; inhibitor; inhibition; porphyrin ... See more keywords
Influence of breast cancer resistance protein and P‐glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice
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DOI: 10.1016/j.ejps.2018.01.034
Abstract: Abstract Ko143 is a reference inhibitor of the adenosine triphosphate‐binding cassette (ABC) transporter breast cancer resistance protein (humans: ABCG2, rodents: Abcg2) for in vitro and in vivo use. Previous in vitro data indicate that Ko143… read more here.
Keywords: excretion; 11c ko143; ko143; mice ... See more keywords
Repression of adenosine triphosphate–binding cassette transporter ABCG2 by estrogen increases intracellular glutathione in brain endothelial cells following ischemic reperfusion injury
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.02.020
Abstract: The adenosine triphosphate-binding cassette efflux transporter ABCG2, which is located in the blood-brain barrier limits the entry of endogenous compounds and xenobiotics into the brain, and its expression and activity are regulated by estrogen. This… read more here.
Keywords: abcg2 estrogen; brain; abcg2; injury ... See more keywords
Contrasting roles of the ABCG2 Q141K variant in prostate cancer
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.03.020
Abstract: ABSTRACT ABCG2 is a membrane transport protein that effluxes growth‐promoting molecules, such as folates and dihydrotestosterone, as well as chemotherapeutic agents. Therefore it is important to determine how variants of ABCG2 affect the transporter function… read more here.
Keywords: q141k variant; abcg2; prostate cancer;
The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
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DOI: 10.1038/s41467-020-16525-w
Abstract: The pathophysiological nature of the common ABCG2 gout and hyperuricemia associated variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find that… read more here.
Keywords: urate excretion; physiology; q141k; gout ... See more keywords
Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2
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DOI: 10.1042/bcj20190873
Abstract: Hereditary hemochromatosis (HH) is mostly caused by mutations in the iron-regulatory gene HFE. The disease is associated with iron overload, resulting in liver cirrhosis/cancer, cardiomegaly, kidney dysfunction, diabetes, and arthritis. Fe2+-induced oxidative damage is suspected… read more here.
Keywords: expression; etiology; xanthine oxidase; abcg2 ... See more keywords
ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population.
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DOI: 10.1080/03014460.2022.2140826
Abstract: BACKGROUND Organic anion transporting polypeptide 1B1 (OATP1B1) and the ATP-binding cassette subfamily G member 2, ABCG2, are important transporters involved in the transport of endogenous substrates and xenobiotics, including drugs. Genetic polymorphisms of these transporters… read more here.
Keywords: slco1b1 gene; frequency; abcg2; croatian population ... See more keywords
P0169DYSFUNCTION OF ABCG2, URATE TRANSPORTER, IS RELATED WITH UROLITHIASIS
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0169
Abstract: Urolithiasis is one of the rapidly increasing diseases in developed countries. It has been reported that urolithiasis is related with lifestyles, diet, obesity, climate and chronic diseases including hyperuricemia, diabetes mellitus, metabolic syndrome, chronic kidney… read more here.
Keywords: uric acid; renal uric; urolithiasis; abcg2 ... See more keywords
Stemness and anti‐cancer drug resistance in ATP‐binding cassette subfamily G member 2 highly expressed pancreatic cancer is induced in 3D culture conditions
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DOI: 10.1111/cas.13533
Abstract: The expression of ATP‐binding cassette subfamily G member 2 (ABCG2) is related to tumorigenic cancer stem cells (CSC) in several cancers. However, the effects of ABCG2 on CSC‐related malignant characteristics in pancreatic ductal adenocarcinoma (PDAC)… read more here.
Keywords: drug resistance; abcg2 cells; cancer; abcg2 ... See more keywords