Aberrant Caspase Activation in Laminin-α2-Deficient Human Myogenic Cells is Mediated by p53 and Sirtuin Activity
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DOI: 10.3233/jnd-170262
Abstract: Background: Mutations in the LAMA2 gene encoding laminin-α2 cause congenital muscular dystrophy Type 1A (MDC1A), a severe recessive disease with no effective treatment. Previous studies have shown that aberrant activation of caspases and cell death… read more here.
Keywords: caspase activation; aberrant caspase; myogenic cells; activation ... See more keywords