Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.082
Abstract: The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify aberrant DNA methylation and… read more here.
Keywords: dna; aberrant dna; human tumors; cancer ... See more keywords
Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34612-3
Abstract: Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells… read more here.
Keywords: methylation tgfb1; mesangial cells; tgfb1; aberrant dna ... See more keywords
Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83185-1
Abstract: We hypothesized that epigenetics is a link between smoking/allergen exposures and the development of Asthma and chronic obstructive pulmonary disease (ACO). A total of 75 of 228 COPD patients were identified as ACO, which was… read more here.
Keywords: chronic obstructive; asthma chronic; obstructive pulmonary; dna methylations ... See more keywords
Polycomb Group Proteins Recruit TET1 to Remove Aberrant DNA Methylation in Murine Embryonic Stem Cells
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-116841
Abstract: At the top of the hematopoietic hierarchy are hematopoietic stem cells (HSCs), which reside in the bone marrow and are characterized by the ability to self-renew or differentiate into various types of mature blood cells.… read more here.
Keywords: methylation; dna; dna methylation; aberrant dna ... See more keywords
Aberrant DNA methylation defines isoform usage in cancer, with functional implications
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DOI: 10.1371/journal.pcbi.1007095
Abstract: Alternative transcript isoforms are common in tumors and act as potential drivers of cancer. Mechanisms determining altered isoform expression include somatic mutations in splice regulatory sites or altered splicing factors. However, since DNA methylation is… read more here.
Keywords: methylation; isoform; aberrant dna; cancer ... See more keywords
Aberrant DNA methylation in multiple myeloma: A major obstacle or an opportunity?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.979569
Abstract: Drug resistance (DR) of cancer cells leading to relapse is a huge problem nowadays to achieve long-lasting cures for cancer patients. This also holds true for the incurable hematological malignancy multiple myeloma (MM), which is… read more here.
Keywords: aberrant dna; methylation; dna methylation; multiple myeloma ... See more keywords
Research Progress of DNA Methylation in Endometrial Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12070938
Abstract: Endometrial cancer (EC)) is one of the most common malignant tumors of the female genital system, with an increasing incidence and mortality, worldwide. Although the therapeutic strategy of EC is still complicated and challenging, further… read more here.
Keywords: aberrant dna; endometrial cancer; methylation; dna methylation ... See more keywords