Aberrant Ki‐67 expression through 3′UTR alternative polyadenylation in breast cancers
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12364
Abstract: Ki‐67 (MKI67) is a marker of cellular proliferation of cancer. Here, we show that Ki‐67 is post‐transcriptionally regulated through alternative polyadenylation (APA) and microRNAs in breast cancer. We show that shortening of the Ki‐67 3′UTR… read more here.
Keywords: breast; aberrant expression; utr alternative; polyadenylation ... See more keywords
Aberrant expression of Sec61α in esophageal cancers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-02955-7
Abstract: IntroductionThe heterotrimeric Sec61α translocon complex is topological located in the membrane of the endoplasmic reticulum (ER) and allows protein transport and calcium across the membrane. Recently, aberrant expression of Sec proteins was linked to carcinogenesis… read more here.
Keywords: sec61; esophageal cancers; aberrant expression; expression sec61 ... See more keywords
Aberrant expression of miRNAs in epilepsy.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07188-5
Abstract: Epilepsy is manifested by intermittent convulsions and alterations in consciousness. This disorder has serious effects on daily functions and physical and mental health of affected patients. A variety of temporary irregularities in the function of… read more here.
Keywords: aberrant expression; mir; epilepsy; expression mirnas ... See more keywords
The histologic, immunohistochemical, and genetic features of classical Hodgkin lymphoma and anaplastic large cell lymphoma with aberrant T-cell/B-cell antigen expression.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2018.10.003
Abstract: Classical Hodgkin lymphoma (cHL) and ALK- anaplastic large cell lymphoma (ALCL) share many morphologic and immunohistochemical features, causing difficulties in differential diagnosis. Aberrant T-cell/B-cell antigen (TCA/BCA) expression in cHL/ALCL has previously been reported, but differences… read more here.
Keywords: aberrant expression; chl alcl; expression; genetic features ... See more keywords
The aberrant expression or disruption of desmocollin2 in human diseases.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.03.041
Abstract: The desmosome is a member of intercellular junctions that named 'anchoring junction', which contributes to the integrity and homeostasis of tissue structure and function of multicellular living organisms. As an important component of the desmosome… read more here.
Keywords: aberrant expression; human diseases; dsc2; expression disruption ... See more keywords
Aberrant expression of BAX, MEG3, and miR-214-3P genes in recurrent pregnancy loss
Sign Up to like & getrecommendations! Published in 2021 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2021.1897098
Abstract: Abstract Aims Recurrent pregnancy loss (RPL), with unknown causes, is one of the most common challenges facing pregnancy. Apoptotic signaling pathways are involved in the normal and abnormal pregnancy process. Despite the evidence pointing toward… read more here.
Keywords: bax meg3; pregnancy; aberrant expression; expression ... See more keywords
ABEILLE: a novel method for ABerrant Expression Identification empLoying machine LEarning from RNA-sequencing data
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac603
Abstract: Abstract Motivation Current advances in omics technologies are paving the diagnosis of rare diseases proposing a complementary assay to identify the responsible gene. The use of transcriptomic data to identify aberrant gene expression (AGE) has… read more here.
Keywords: expression identification; identification; age; expression ... See more keywords
Aberrant expression of claudin‐6 contributes to malignant potentials and drug resistance of cervical adenocarcinoma
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DOI: 10.1111/cas.15284
Abstract: Recent studies have revealed that aberrant expression of tight junction (TJ) proteins is a hallmark of various solid tumors and it is recognized as a useful therapeutic target. Claudin‐6 (CLDN6), a member of the family… read more here.
Keywords: cell; malignant potentials; expression; cervical adenocarcinoma ... See more keywords
Aberrant expression of FLI‐1 in melanoma
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DOI: 10.1111/cup.12979
Abstract: Friend leukemia integration site 1 (FLI‐1) nuclear transcription factor has been proposed as a suitable tool in the differential diagnosis of small round cell sarcomas. It has also been described as a nuclear marker of… read more here.
Keywords: melanoma; aberrant expression; small round; expression ... See more keywords
Aberrant expression of CD10 and BCL6 in mantle cell lymphoma
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DOI: 10.1111/his.13286
Abstract: Mantle cell lymphoma (MCL) is characterized by distinctive histological and molecular features. Aberrant expression of BCL6 and CD10 has been reported occasionally, but the biological features of such cases are largely unknown. This study aimed… read more here.
Keywords: aberrant expression; mantle cell; cell lymphoma;
Role of SMARCA4 (BRG1) and SMARCB1 (INI1) in Dedifferentiated Endometrial Carcinoma With Paradoxical Aberrant Expression of MMR in the Well-Differentiated Component: A Case Report and Review of the Literature
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Surgical Pathology"
DOI: 10.1177/1066896920959453
Abstract: Introduction Dedifferentiated endometrial carcinoma is an uncommon highly aggressive uterine tumor. It comprises 2 components: a well-differentiated, low-grade epithelial carcinoma and an undifferentiated carcinoma. The undifferentiated carcinoma frequently exhibits rhabdoid cytologic features. Many of these… read more here.
Keywords: carcinoma; aberrant expression; well differentiated; endometrial carcinoma ... See more keywords