Novel miRNA genes deregulated by aberrant methylation in ovarian carcinoma are involved in metastasis.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.04.005
Abstract: Methylation of promoter CpG islands may suppress the function of miRNAs by inhibiting their expression. Our work analyzes the role of promoter methylation in altering the expression of 12 miRNAs associated with epithelial ovarian cancer… read more here.
Keywords: methylation; aberrant methylation; mirna genes; metastasis ... See more keywords
Investigation of the effect of P14 promoter aberrant methylation on the biological function of human lung cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13082
Abstract: This study was conducted to investigate the effect of P14 promoter aberrant methylation on the biological function of human lung adenocarcinoma cells. read more here.
Keywords: promoter aberrant; aberrant methylation; biological function; p14 promoter ... See more keywords
Using long-read sequencing to detect and subtype a case with Temple syndrome
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Genetics"
DOI: 10.1136/jmg-2024-110262
Abstract: Temple syndrome is an imprinting disorder resulting from abnormal genomic or epigenomic aberrations of chromosome 14 including maternal uniparental disomy (matUPD), paternal deletion of 14q32, or aberrant methylation of the imprinting control regions at 14q32.… read more here.
Keywords: case temple; temple syndrome; methylation; aberrant methylation ... See more keywords
Variants of NLRP genes encoding subcortical maternal complex components are linked to biparental placental mesenchymal dysplasia
Sign Up to like & getrecommendations! Published in 2025 at "Human Genomics"
DOI: 10.1186/s40246-025-00814-w
Abstract: Placental mesenchymal dysplasia (PMD) is a placental abnormality resembling partial hydatidiform moles without trophoblastic proliferation. Although many PMD cases involve androgenetic/biparental mosaicism or chimerism, we recently reported that approximately 30% of cases retain biparental genomes… read more here.
Keywords: maternal complex; subcortical maternal; methylation; aberrant methylation ... See more keywords