SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function
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DOI: 10.7554/elife.24325
Abstract: NEDD8 is a ubiquitin-like modifier most well-studied for its role in activating the largest family of ubiquitin E3 ligases, the cullin-RING ligases (CRLs). While many non-cullin neddylation substrates have been proposed over the years, validation… read more here.
Keywords: neddylation; cullin ring; pathway components; aberrant neddylation ... See more keywords