Computational prediction and redesign of aberrant protein oligomerization.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.11.002
Abstract: Non-native intermolecular contacts often lead to aberrant protein oligomerization and aggregation. This phenomenon is behind the onset of several human disorders and is a bottleneck for the production of proteins of biotechnological interest. Intrinsically disordered… read more here.
Keywords: aggregation; aberrant protein; protein oligomerization; computational prediction ... See more keywords
Warning signs from the crypt: Aberrant protein glycosylation marks opportunities for early colorectal cancer detection.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and translational gastroenterology"
DOI: 10.14309/ctg.0000000000000592
Abstract: ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer-related deaths despite being the most preventable and treatable forms of cancer when caught early through screening. There is an unmet need for novel screening approaches… read more here.
Keywords: protein glycosylation; crypt; glycosylation; colorectal cancer ... See more keywords
Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00098
Abstract: Chaperones have long been recognized to play well defined functions such as to: (i) assist protein folding and promote formation and maintenance of multisubunit complexes; (ii) mediate protein degradation; (iii) inhibit protein aggregation; and (iv)… read more here.
Keywords: aberrant protein; protein aggregates; toxicity; chaperones suppressors ... See more keywords
Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1018333
Abstract: COPYRIGHT © 2022 Sato, Sasaki, Hara, Kobayashi, Doki, Eguchi, Satoh and Ishii. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in… read more here.
Keywords: regulation aberrant; targeting regulation; protein production; pathway gastrointestinal ... See more keywords