Erasing “bad memories”: reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Psychiatry"
DOI: 10.1038/s41380-025-03013-0
Abstract: Dopamine modulates corticostriatal plasticity in both the direct and indirect pathways of the cortico-striato-thalamo-cortical (CSTC) loops. These gradual changes in corticostriatal synaptic strengths produce long-lasting changes in behavioral responses. Under normal conditions, these mechanisms enable… read more here.
Keywords: therapy; neurological psychiatric; plasticity; aberrant synaptic ... See more keywords
Signaling abnormality leading to excessive/aberrant synaptic plasticity in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1062519
Abstract: COPYRIGHT © 2022 Kawabata. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s)… read more here.
Keywords: signaling abnormality; abnormality leading; leading excessive; aberrant synaptic ... See more keywords
Aberrant Synaptic PTEN in Symptomatic Alzheimer’s Patients May Link Synaptic Depression to Network Failure
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2021.683290
Abstract: In Alzheimer’s disease (AD), Amyloid β (Aβ) impairs synaptic function by inhibiting long-term potentiation (LTP), and by facilitating long-term depression (LTD). There is now evidence from AD models that Aβ provokes this shift toward synaptic… read more here.
Keywords: depression; synaptic pten; aberrant synaptic; synaptic depression ... See more keywords