Enantioselective Total Synthesis of (+)-Aberrarone.
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DOI: 10.1021/jacs.2c07150
Abstract: We disclose the first total synthesis of (+)-aberrarone, a diterpenoid natural product featuring a 5-5-5-6-fused tetracyclic skeleton. Key to the approach is a Au-catalyzed-Sn-mediated Meyer-Schuster-Nazarov-cyclopropanation-aldol cascade, which closes four rings in high yield. The convergent… read more here.
Keywords: synthesis; synthesis aberrarone; aberrarone; enantioselective total ... See more keywords
Total Synthesis of (+)-Aberrarone.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1055/s-0042-1752999
Abstract: The structurally intriguing diterpene (+)-aberrarone has been assembled in only 12 steps from the commercially available (S,S)-carveol without protecting group manipulations. This concise synthesis features a Cu-catalyzed asymmetric hydroboration to generate the chiral methyl group,… read more here.
Keywords: total synthesis; synthesis aberrarone; aberrarone; synthesis ... See more keywords
Synthetic study toward the diterpenoid aberrarone
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.18.173
Abstract: An approach to aberrarone, an antimalarial diterpenoid natural product with tetracyclic skeleton is reported. Key to the stereoselective preparation of the 6-5-5 tricyclic skeleton includes the mediation of Nagata reagent for constructing the C1 all-carbon… read more here.
Keywords: study toward; synthetic study; diterpenoid aberrarone; chemistry ... See more keywords