Novel Abietane type Sugar Triazole Hybrids and Amides against SARS‐CoV‐2 Spike Glycoprotein and Influenza A Virus
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400227
Abstract: Abietane type diterpenic (dehydroabietic, 2,3‐dihydroquinopimaric and maleopimaric) acids were converted by the acid chloride method into a series of aliphatic and heterocyclic amine spacered conjugates. A number of structurally novel derivatives holding 1,2,3‐triazole moieties were… read more here.
Keywords: sars cov; chemistry; influenza virus; abietane type ... See more keywords
Cytotoxic ent-Abietane-type diterpenoids from the roots of Euphorbia ebracteolata.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.07.032
Abstract: Euphoroids A-C (1-3), three new ent-abietane-type diterpenoids, together with ten known analogues (4-13) were obtained from the roots of Euphorbia ebracteolata. The structures of these compounds were determined by extensive spectroscopic data analysis, including UV,… read more here.
Keywords: roots euphorbia; abietane type; type diterpenoids; ent abietane ... See more keywords
Cytotoxic abietane-type diterpenoids from twigs and leaves of Croton laevigatus
Sign Up to like & getrecommendations! Published in 2017 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2017.10.007
Abstract: Abstract Seven new abietane-type diterpenoids, crotolaevigatones A–G (1–7), one new aromatic compound, hexyl Z-ferulate (8), along with three known diterpenoids (9–11) and one known aromatic ester, hexyl E-ferulate (12), were obtained from the twigs and… read more here.
Keywords: twigs leaves; croton laevigatus; abietane type; type diterpenoids ... See more keywords
Euphohelides A-C, ent-Abietane-Type Norditerpene Lactones from Euphorbia helioscopia and Their Anti-Inflammatory Activities.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.3c00041
Abstract: Three unreported ent-abietane-type norditerpene lactones, euphohelides A-C (1-3), and 11 known analogs (4-14) were isolated from the whole plants of Euphorbia helioscopia L. Euphohelide A (1) is an unprecedented 2-nor-ent-abietane lactone bearing a unique 5/6/6/5… read more here.
Keywords: ent abietane; type norditerpene; euphorbia helioscopia; norditerpene lactones ... See more keywords
Isolation and Bioinspired Total Synthesis of Rugosiformisin A, A Skeleton-Rearranged Abietane-Type Diterpenoid from Isodon rugosiformis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02834
Abstract: Rugosiformisin A, a skeleton-rearranged abietane-type diterpenoid with a spiro[4.5]decane motif, was isolated from Isodon rugosiformis. Its structure was unambiguously established via NMR spectroscopic analysis and single-crystal X-ray diffraction. A bioinspired asymmetric synthesis of rugosiformisin A… read more here.
Keywords: rugosiformisin; synthesis; skeleton rearranged; rearranged abietane ... See more keywords
Sustainable leads for hypoxic tumor therapy: allosteric selective inhibition of carbonic anhydrase IX by abietane-type resin acids
Sign Up to like & getrecommendations! Published in 2025 at "RSC Advances"
DOI: 10.1039/d5ra05372b
Abstract: Carbonic anhydrase IX (CA IX) helps hypoxic tumors maintain the acidic extracellular milieu that drives invasion and therapy resistance, making it an attractive but still under-exploited drug target. Here we report that four abietane-type resin… read more here.
Keywords: carbonic anhydrase; resin acids; abietane; type resin ... See more keywords
Antimicrobial ent-abietane-type diterpenoids from the roots of Euphorbia wallichii
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2020.1758931
Abstract: Abstract Three previously undescribed ent-abietane-type diterpenoids, designated as 11β-hydroxy-14-oxo-17-al-ent-abieta-8(9),13(15)-dien-16,12β-olide (1), 11β,17-dihydroxy-12-methoxy-ent-abieta-8(14),13(15)-dien-16,12ɑ-olide (2), and 14ɑ-hydroxy-17-al-ent-abieta-7(8),11(12),13(15)-trien-16,12-olide (3), were isolated from 95% ethanol extract of the roots of Euphorbia wallichii. The structures of the new compounds were elucidated… read more here.
Keywords: euphorbia wallichii; roots euphorbia; ent; abietane type ... See more keywords
SARS-CoV-2 main protease and papain-like protease inhibition by abietane-type diterpenes isolated from the branches of Glyptostrobus pensilis using molecular docking studies
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2022.2025801
Abstract: Abstract Using various chromatographic methods, five abietane-type diterpenes were isolated from the branches of Glyptostrobus pensilis for the first time. The chemical structures of the isolates were identified by modern spectroscopic techniques, including 1H and… read more here.
Keywords: protease; diterpenes isolated; type diterpenes; abietane type ... See more keywords
Lanostane-Type Triterpenes and Abietane-Type Diterpene from the Sclerotia of Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), and Their Biological Activities.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of medicinal mushrooms"
DOI: 10.1615/intjmedmushrooms.2018026007
Abstract: Three new lanostane-type triterpenes (compounds 1-3), 1 new abietane-type diterpene (compound 4), and 10 known compounds (5-14) were isolated from sclerotia of Inonotus obliquus. Their structures were elucidated through a combination of spectrometric techniques, including… read more here.
Keywords: inonotus obliquus; type diterpene; type triterpenes; lanostane type ... See more keywords
Abietane-Type Diterpenoids from the Arils of Torreya grandis
Sign Up to like & getrecommendations! Published in 2024 at "Molecules"
DOI: 10.3390/molecules29091905
Abstract: A chemical investigation of the arils of Torreya grandis led to the isolation of seven abietane-type diterpenoids (compounds 1–7) including three previously undescribed compounds, one unreported natural product, and three known analogs. The structures of… read more here.
Keywords: diterpenoids arils; arils torreya; type diterpenoids; abietane type ... See more keywords