Improving the ability of CAR-T cells to hit solid tumors: challenges and strategies.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.106036
Abstract: Chimeric antigen receptor T cell (CAR-T) therapy is a late-model of immune cell therapy that has been shown to be effective in refractory/recurrent B-cell leukemia and lymphoma. Compared with the traditional anti-tumor methods, CAR-T cell… read more here.
Keywords: ability car; solid tumors; car cells; cell ... See more keywords
Induced expression of CCL19 promotes the anti-tumor ability of CAR-T cells by increasing their infiltration ability
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.958960
Abstract: Background Chimeric antigen receptor-engineered T cell (CAR-T) therapy has shown promising potential for anti-cancer treatment. However, for pancreatic ductal adenocarcinoma (PDAC), the lack of infiltrative ability of these CAR-T cells leads to sub-optimal treatment outcome.… read more here.
Keywords: ability car; tumor; car; car cells ... See more keywords