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   Articles with "abl" as a keyword



Antimicrobial Blue Light for decontamination of platelets during storage.

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recommendations! Published in 2019 at "Journal of biophotonics"

DOI: 10.1002/jbio.201960021

Abstract: Platelet (PLT) storage is currently limited to 5 days in clinics in the United States, in part, due to an increasing risk for microbial contamination over time. In light of well-documented antimicrobial activity of blue light… read more here.

Keywords: blue light; storage; plt storage; antimicrobial blue ... See more keywords

Abaloparatide excels teriparatide in protecting against alveolar bone loss in experimental periodontitis.

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recommendations! Published in 2022 at "Journal of periodontology"

DOI: 10.1002/jper.22-0211

Abstract: BACKGROUND It was aimed to compare the effects of two osteoanabolic drugs, abaloparatide (ABL) and teriparatide (TPTD), on protecting alveolar bone in experimental periodontitis. METHODS Twenty-four 9-week-old male Sprague-Dawley rats were placed with silk ligature… read more here.

Keywords: experimental periodontitis; abl; alveolar bone; abl tptd ... See more keywords

Self-management of accidental bowel leakage and interest in a supportive m-Health app among women

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recommendations! Published in 2019 at "International Urogynecology Journal"

DOI: 10.1007/s00192-019-04192-5

Abstract: Introduction Self-management with clinician guidance is a cornerstone of successful conservative treatment for accidental bowel leakage (ABL). There are currently few resources to assist patients with that essential self-management. The purpose of this study was… read more here.

Keywords: health app; management; interest; self management ... See more keywords
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A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation.

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recommendations! Published in 2017 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2016.11.013

Abstract: Neurite outgrowth is a critical step for neurogenesis and remodeling synaptic circuitry during neuronal development and regeneration. An immunoglobulin superfamily member, BOC functions as Sonic hedgehog (Shh) coreceptor in canonical and noncanonical Shh signaling in… read more here.

Keywords: boc; jnk; differentiation; activation ... See more keywords

Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML).

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recommendations! Published in 2021 at "European journal of pharmacology"

DOI: 10.1016/j.ejphar.2021.173944

Abstract: As the critical driving force for chronic myeloid leukemia (CML), BCR gene fused ABL kinase has been extensively explored as a validated target of drug discovery. Although imatinib has achieved tremendous success as the first-line… read more here.

Keywords: cml; kinase; bcr abl; imatinib ... See more keywords

Normal plasma apoB48 despite the virtual absence of apoB100 in a compound heterozygote with novel mutations in the MTTP gene.

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recommendations! Published in 2021 at "Journal of clinical lipidology"

DOI: 10.1016/j.jacl.2021.04.013

Abstract: "Normotriglyceridemic abetalipoproteinemia (ABL)" was originally described as a clinical entity distinct from either ABL or hypobetalipoproteinemia. Subsequent studies identified mutations in APOB gene which encoded truncated apoB longer than apoB48. Therefore, "Normotriglyceridemic ABL" can be… read more here.

Keywords: plasma apob48; apob48 despite; despite virtual; normal plasma ... See more keywords

1-O-Actylbritannilactone Ameliorates Alcohol-Induced Hepatotoxicity through Regulation of ROS/Akt/NF-κB-Mediated Apoptosis and Inflammation

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c01681

Abstract: 1-O-Acetylbritannilactone (ABL) is a marker component of Inula britannica L. and is reported to exhibit multiple pharmacological activities, including antiaging, anti-inflammatory, and antidiabetic properties. Although the protective effect of Inula britannica L. on animal models… read more here.

Keywords: apoptosis; ros akt; regulation ros; abl ... See more keywords

The Discovery of Abl Kinase ATPase Activity and Its Implications in the Development of Straightforward Assays

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recommendations! Published in 2025 at "ACS Omega"

DOI: 10.1021/acsomega.5c08176

Abstract: Abelson kinase (Abl) is an enzyme crucial in metabolic pathways, and it is a molecular target for leukemias, especially chronic myeloid leukemia. Despite extensive research on its kinase function and inhibition over the years, there… read more here.

Keywords: atpase activity; kinase; discovery; abl ... See more keywords
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Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets

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recommendations! Published in 2020 at "Leukemia"

DOI: 10.1038/s41375-020-01082-4

Abstract: The oncogenic protein Bcr-Abl has two major isoforms, p190Bcr-Abl and p210Bcr-Abl. While p210Bcr-Abl is the hallmark of chronic myeloid leukemia (CML), p190Bcr-Abl occurs in the majority of Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) patients. In CML,… read more here.

Keywords: cml; bcr abl; leukemia; p190bcr abl ... See more keywords

USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia

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recommendations! Published in 2019 at "Cell Discovery"

DOI: 10.1038/s41421-019-0092-z

Abstract: Constitutive activation of tyrosine kinase Bcr-Abl is the leading cause of the development and progression of chronic myeloid leukemia (CML). Currently, the application of tyrosine kinase inhibitors (TKIs) targeting the Bcr-Abl is the primary therapy… read more here.

Keywords: cml; myeloid leukemia; bcr abl; chronic myeloid ... See more keywords

Tyrosine kinase c-Abl regulates the survival of plasma cells

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep40133

Abstract: Tyrosine kinase c-Abl plays an important role in early B cell development. Its deletion leads to reduced pro- and pre-B cell generation in mice. However, its function in B cell terminal differentiation remains unexplored. Here,… read more here.

Keywords: plasma cells; regulates survival; kinase abl; tyrosine kinase ... See more keywords