A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
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DOI: 10.1038/s41467-019-12656-x
Abstract: Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key role in B-ALL. Loss of CDK8 in leukemia mouse models significantly enhances disease latency… read more here.
Keywords: abl1 leukemia; cdk8; mtor; role ... See more keywords