A Review on the Role of Molecular Genetics in the Diagnostic Workup of BCR::ABL1 -Negative Myeloproliferative Neoplasms
Sign Up to like & getrecommendations! Published in 2023 at "Indian Journal of Medical and Paediatric Oncology"
DOI: 10.1055/s-0043-1766138
Abstract: Abstract The diagnostic evaluation of myeloproliferative neoplasms (MPNs) depends on the close correlation between clinical features, morphologic assessment of a trephine bone marrow biopsy, and molecular markers. Typically, MPNs have driver mutations in JAK2 ,… read more here.
Keywords: role molecular; bcr abl1; abl1 negative; myeloproliferative neoplasms ... See more keywords
Atypical neutrophilic panniculitis as presentation of BCR-ABL1-negative chronic myeloid leukaemia
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DOI: 10.1136/bcr-2019-232005
Abstract: We report the case of an otherwise healthy 60-year-old man presenting with fever, leucocytosis and a painful swelling of the right calf. We initially performed cultural and cytological examination of the popliteal fossa mass, but… read more here.
Keywords: neutrophilic panniculitis; abl1 negative; myeloid leukaemia; chronic myeloid ... See more keywords
Molecular Classification Improves Risk Assessment in Adult BCR-ABL1-negative B-ALL.
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DOI: 10.1182/blood.2020010144
Abstract: Genomic classification has improved risk assignment of pediatric but not adult B-lineage acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (NCT00002514) trial accrued 1229 BCR-ABL1-negative adolescent/adult B-ALL patients (aged 14-65 years). While 93% of patients… read more here.
Keywords: molecular classification; risk; adult; abl1 negative ... See more keywords
Atypical Chronic Myelogenous Leukemia, BCR-ABL1 Negative: Diagnostic Criteria and Treatment Approaches
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DOI: 10.3389/fonc.2021.722507
Abstract: Atypical chronic myelogenous leukemia (aCML), BCR/ABL1 negative is a rare myelodysplastic/myeloproliferative neoplasm, usually manifested with hyperleukocytosis without monocytosis or basophilia, organomegaly, and marked dysgranulopoiesis. In this review, we will discuss the classification and diagnostic criteria… read more here.
Keywords: atypical chronic; myelogenous leukemia; bcr abl1; diagnostic criteria ... See more keywords
[BCR-ABL1 negative chronic myeloid leukemia: report of two cases].
Sign Up to like & getrecommendations! Published in 2022 at "Revista medica de Chile"
DOI: 10.4067/s0034-98872022000300397
Abstract: BCR-ABL1 negative atypical chronic myeloid leukemia (aCML) is a rare type of myeloproliferative / myelodysplastic syndrome characterized by leukocytosis and proliferation of dysplastic neutrophilic precursors in the absence of positivity for the BCR-ABL1 fusion gene.… read more here.
Keywords: myeloid leukemia; chronic myeloid; report; bcr abl1 ... See more keywords