Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shock protein 27.
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DOI: 10.1016/j.ejmech.2017.08.065
Abstract: Heat Shock Protein 27 (HSP27) is a member of small heat shock proteins with a highly-conserved α-crystalline domain. It inhibits aggregation of damaged proteins through a complex structural systems of phosphorylation-dependent oligomerization and self-assembly. It… read more here.
Keywords: heat shock; shock protein; abnormal hsp27; heat ... See more keywords