Unraveling the Abnormal Molecular Mechanism of Suicide Inhibition of Cytochrome P450 3A4
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c01035
Abstract: Suicide inhibition of the CYP3A4 enzyme by a drug inactivates the enzyme in the drug biotransformation process and often shows safety concerns about the drug. Despite extensive experimental studies, the abnormal molecular mechanism of a… read more here.
Keywords: suicide inhibition; abnormal molecular; molecular mechanism; mechanism suicide ... See more keywords
Identification of Clinically Relevant Subgroups of Chronic Lymphocytic Leukemia Through Discovery of Abnormal Molecular Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.627964
Abstract: Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia in the Western world with a highly variable clinical course. Its striking genetic heterogeneity is not yet fully understood. Although the CLL genetic… read more here.
Keywords: lymphocytic leukemia; abnormal molecular; identification clinically; chronic lymphocytic ... See more keywords