Novel mutations in FSIP2 lead to multiple morphological abnormalities of the sperm flagella and poor ICSI prognosis.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145536
Abstract: Multiple morphological abnormalities of the sperm flagella (MMAF) is defined as deformities that cause sperm motility disorders, further resulting in male infertility. However, the reported genes related to sperm flagellar defects can only explain approximately… read more here.
Keywords: morphological abnormalities; abnormalities sperm; sperm flagella; novel mutations ... See more keywords
The effect of ionomycin-induced oocyte activation on multiple morphological abnormalities of the sperm flagella
Sign Up to like & getrecommendations! Published in 2023 at "Systems Biology in Reproductive Medicine"
DOI: 10.1080/19396368.2023.2167621
Abstract: Abstract Artificial oocyte activation (AOA) is considered an effective method to improve clinical outcomes in patients with some forms of male factor infertility and does not increase the risk of birth defects. However, the effects… read more here.
Keywords: clinical outcomes; oocyte activation; multiple morphological; abnormalities sperm ... See more keywords
Novel compound heterozygous variants of DNAH17 in a Chinese infertile man with multiple morphological abnormalities of sperm flagella
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14553
Abstract: Multiple morphological abnormalities of the sperm flagellum (MMAF) have been reported to be an important cause of male infertility and reflect a heterogeneous genetic disorder. Previous studies have identified dozens of candidate pathogenic genes for… read more here.
Keywords: heterozygous variants; compound heterozygous; multiple morphological; abnormalities sperm ... See more keywords
Biallelic mutations of CFAP58 are associated with multiple morphological abnormalities of the sperm flagella
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Genetics"
DOI: 10.1111/cge.13898
Abstract: Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe type of teratozoospermia. In this study, whole‐exome sequencing was conducted on 55 patients with MMAF, and biallelic mutations of CFAP58 were identified in two… read more here.
Keywords: morphological abnormalities; abnormalities sperm; sperm flagella; multiple morphological ... See more keywords