Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N-acetyltransferase.
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DOI: 10.1002/1873-3468.14360
Abstract: Mycobacterium abscessus is a pathogenic non-tuberculous mycobacterium that possesses an intrinsic drug-resistance profile. Several N-acetyltransferases mediate drug resistance and/or participate in M. abscessus virulence. Mining the M. abscessus genome has revealed genes encoding additional N-acetyltransferases… read more here.
Keywords: mab 4324c; mycobacterium abscessus; abscessus; biochemical structural ... See more keywords
Structure‐Based Design and Synthesis of Piperidinol‐Containing Molecules as New Mycobacterium abscessus Inhibitors
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DOI: 10.1002/open.202000042
Abstract: Abstract Non‐tuberculous mycobacterium (NTM) infections, such as those caused by Mycobacterium abscessus, are increasing globally. Due to their intrinsic drug resistance, M. abscessus pulmonary infections are often difficult to cure using standard chemotherapy. We previously… read more here.
Keywords: mycobacterium; piperidinol; abscessus; structure based ... See more keywords
Effect of amikacin on cell wall glycopeptidolipid synthesis in Mycobacterium abscessus
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DOI: 10.1007/s12275-017-6503-7
Abstract: Cultivation of the smooth colony Mycobacterium abscessus at the sub-minimum inhibitory concentration (MIC) of amikacin changed its growth pattern including its colony morphology (smooth to rough) and cell arrangement (dispersed to cord formation). In addition,… read more here.
Keywords: cell wall; amikacin; abscessus; mycobacterium abscessus ... See more keywords
Incidental intraoperative diagnosis of Mycobacterium abscessus meningeal infection: a case report and review of the literature
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DOI: 10.1007/s15010-018-1141-5
Abstract: PurposeMycobacterium abscessus, and rapidly growing mycobacteria in general, are rare but increasing causes of central nervous system (CNS) infections. The aim of this study is to highlight the importance of considering these microorganism in the… read more here.
Keywords: literature; diagnosis; meningeal infection; infection ... See more keywords
Treatment of Mycobacterium abscessus Pulmonary Disease.
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DOI: 10.1016/j.chest.2021.07.035
Abstract: Mycobacterium abscessus is the second most common nontuberculous mycobacterial lung disease pathogen and comprises three subspecies, abscessus, massiliense and bolletii. Subspecies identification is critical for disease management as subspecies abscessus and bolletii have an inducible… read more here.
Keywords: treatment; disease; abscessus; macrolide resistance ... See more keywords
Antimicrobial susceptibility profiles of Mycobacterium abscessus complex isolated from respiratory specimens in Shanghai, China.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2021.02.024
Abstract: OBJECTIVES To compare the antibiotic susceptibility profiles of Mycobacterium abscessus complex (MABC) and investigate the relationship between susceptibility profiles and genetic mechanism of macrolides resistance. METHODS Over 200 isolates collected from respiratory specimens between 2014… read more here.
Keywords: susceptibility; profiles mycobacterium; abscessus complex; abscessus ... See more keywords
Case report on pulmonary disease due to coinfection of Mycobacterium tuberculosis and Mycobacterium abscessus: Difficulty in diagnosis
Sign Up to like & getrecommendations! Published in 2017 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2017.01.011
Abstract: Mycobacterium abscessus, which is ubiquitous environmental organism, is more likely to cause pulmonary infection in the presence underlying lung disease and immunosuppression. We report a case of pulmonary disease due to coinfection of Mycobacterium tuberculosis… read more here.
Keywords: mycobacterium; abscessus; case; pulmonary disease ... See more keywords
Clinico-microbiological analysis of 121 patients with pulmonary Mycobacteroides abscessus complex disease in Japan - An NTM-JRC study with RIT.
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DOI: 10.1016/j.rmed.2018.10.012
Abstract: RATIONALE No comprehensive analysis has previously been performed to evaluate the clinical aspects of and microbiological evidence associated with Mycobacteroides abscessus complex (MABC) infection in a region, such as Japan, with a low MABC incidence.… read more here.
Keywords: abscessus complex; analysis; mycobacteroides abscessus; abscessus ... See more keywords
Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria.
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DOI: 10.1021/acs.jmedchem.3c00009
Abstract: Nα-2-thiophenoyl-d-phenylalanine-2-morpholinoanilide [MMV688845, Pathogen Box; Medicines for Malaria Venture; IUPAC: (2R)-N-(1-((2-morpholinophenyl)amino)-1-oxo-3-phenylpropan-2-yl)thiophene-2-carboxamide)] is a hit compound, which shows activity against Mycobacterium abscessus (MIC90 6.25-12.5 μM) and other mycobacteria. This work describes derivatization of MMV688845 by introducing a… read more here.
Keywords: phenylalanine; mycobacterium abscessus; synthesis; mycobacterium ... See more keywords
High-Throughput Screening Identifies Synthetic Peptides with Antibacterial Activity against Mycobacterium abscessus and Serum Stability
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DOI: 10.1021/acsomega.2c02844
Abstract: The rise in antibiotic resistance in bacteria has spawned new technological approaches for identifying novel antimicrobials with narrow specificity. Current antibiotic treatment regimens and antituberculosis drugs are not effective in treating Mycobacterium abscessus. Meanwhile, antimicrobial… read more here.
Keywords: antibacterial activity; synthetic peptides; mycobacterium abscessus; activity ... See more keywords
Effect of Panax quinquefolius extract on Mycobacterium abscessus biofilm formation
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DOI: 10.1080/08927014.2023.2166405
Abstract: Abstract Mycobacterium abscessus (M. abscessus) can exist either as planktonic bacteria or as a biofilm. Biofilm formation is one of the important causes of conversion to resistance to antibiotics of bacteria that were previously sensitive… read more here.
Keywords: quinquefolius extract; biofilm formation; mycobacterium abscessus; panax quinquefolius ... See more keywords