Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120604
Abstract: Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the… read more here.
Keywords: melanoma; celastrol nanoemulsion; tumor cells; abscopal effect ... See more keywords
[Abscopal effect: Myth or reality?]
Sign Up to like & getrecommendations! Published in 2021 at "Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique"
DOI: 10.1016/j.canrad.2021.07.002
Abstract: The abscopal effect has been mentioned since 1953. The increase in knowledge about the immune system and the development of immunotherapies support its potential therapeutic interest. While it is accepted that radiotherapy induces an immune… read more here.
Keywords: myth reality; immunotherapy; radiotherapy; effect ... See more keywords
Abscopal effect in radioimmunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106663
Abstract: Abscopal effect is an interesting phenomenon in radiobiology that causes activation of immune system against cancer cells. Traditionally, this phenomenon was known as a suppressor of non-irradiated tumors or metastasis. However, it can be used… read more here.
Keywords: effect; immune system; anti tumor; abscopal effect ... See more keywords
Using immunotherapy to boost the abscopal effect
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cancer"
DOI: 10.1038/nrc.2018.6
Abstract: More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression of metastatic cancer at distant sites that are not irradiated was described and called the abscopal effect (from 'ab… read more here.
Keywords: effect; boost abscopal; using immunotherapy; abscopal effect ... See more keywords
Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model
Sign Up to like & getrecommendations! Published in 2017 at "Oncoimmunology"
DOI: 10.1080/2162402x.2017.1338236
Abstract: ABSTRACT LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic immune response in a rat fibrosarcoma… read more here.
Keywords: ltx 315; oncolytic peptide; model; abscopal effect ... See more keywords
Valproic acid triggers radiation-induced abscopal effect by modulating the unirradiated tumor immune microenvironment in a rat model of breast cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of radiation research"
DOI: 10.1093/jrr/rrab037
Abstract: An abscopal effect occurs when localized radiotherapy causes the regression of tumors distant from the irradiated site. However, such a clinically detectable abscopal effect from radiotherapy alone is rare. This study investigated whether valproic acid… read more here.
Keywords: radiation induced; unirradiated tumor; abscopal effect; tumor ... See more keywords
Radiation therapy induces an abscopal effect and upregulates programmed death‐ligand 1 expression in a patient with non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14330
Abstract: Radiation therapy (RT) activates the antigen presentation of dendritic cells and priming of cancer‐specific cytotoxic CD8+ T cells, occasionally resulting in a systemic immune response to the tumor outside of the treatment field. The phenomenon… read more here.
Keywords: abscopal effect; therapy; death; patient ... See more keywords
Tumor microenvironment shows an immunological abscopal effect in patients with NSCLC treated with pembrolizumab-radiotherapy combination
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005248
Abstract: Background Immunotherapy is currently part of the standard of care for patients with advanced-stage non-small cell lung cancer (NSCLC). However, many patients do not respond to this treatment, therefore combination strategies are being explored to… read more here.
Keywords: immunological abscopal; abscopal effect; treated pembrolizumab; combination ... See more keywords
Abstract 3742: Exosome-mediated EGR1 transportation controls the radiation-induced abscopal effect in head and neck cancer
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-3742
Abstract: Head and neck cancer (HNC) are one of the vital types of metastatic cancer, and radiotherapy (RT) is the convincing treatment regarding its location. RT can regulate cancer growth in not only directly irradiated cells… read more here.
Keywords: radiation; exosome; cancer; radiation induced ... See more keywords
Abstract 1099: Combined treatment with direct hydrogen peroxide administration and irradiation promotes an abscopal effect in mouse models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1099
Abstract: Background: Hydrogen peroxide (H2O2) causes oxidative stress and cytotoxicity and may be used in cancer therapy in combination with radiotherapy (RT). Indeed, H2O2 has been clinically developed as a radiosensitizer (development code: KRC-01). However, effects… read more here.
Keywords: hydrogen peroxide; effect; abscopal effect; mouse models ... See more keywords
Differential abscopal effect in extracranial and intracranial lesions after radiotherapy alone for vertebral bone metastasis of unknown primary: a case report
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Case Reports"
DOI: 10.1186/s13256-022-03321-x
Abstract: The abscopal effect is a phenomenon in which a tumor located far from irradiated lesions regresses. We have experienced a case in which both intracranial and extracranial lesions showed an abscopal effect after radiotherapy for… read more here.
Keywords: effect; intracranial lesions; case; abscopal effect ... See more keywords