In-situ vaccination using focused ultrasound heating and anti-CD-40 agonistic antibody enhances T-cell mediated local and abscopal effects in murine melanoma
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2019.1663280
Abstract: Abstract The success of melanoma immunotherapy is dependent on the presence of activated and functional T-cells in tumors. The objective of this study was to investigate the impact of local-focused ultrasound (FUS) heating (∼42–45 °C) and… read more here.
Keywords: melanoma; focused ultrasound; agonistic antibody; abscopal effects ... See more keywords
TGFβ Blockade Enhances Radiotherapy Abscopal Efficacy Effects in Combination with Anti-PD1 and Anti-CD137 Immunostimulatory Monoclonal Antibodies
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-18-0558
Abstract: Radiotherapy can be synergistically combined with immunotherapy in mouse models, extending its efficacious effects outside of the irradiated field (abscopal effects). We previously reported that a regimen encompassing local radiotherapy in combination with anti-CD137 plus… read more here.
Keywords: tgf blockade; combination; efficacy; anti cd137 ... See more keywords