A machine‐learning approach for predicting impaired consciousness in absence epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51647
Abstract: Behavior during 3–4 Hz spike‐wave discharges (SWDs) in absence epilepsy can vary from obvious behavioral arrest to no detectible deficits. Knowing if behavior is impaired is crucial for clinical care but may be difficult to determine… read more here.
Keywords: absence epilepsy; machine learning; absence; impaired consciousness ... See more keywords
Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Neurology"
DOI: 10.1002/ana.24886
Abstract: To determine whether common polymorphisms in CACNA1G, CACNA1H, CACNA1I, and ABCB1 are associated with differential short‐term seizure outcome in childhood absence epilepsy (CAE). read more here.
Keywords: pharmacogenetics antiepileptic; childhood absence; absence epilepsy;
Fingolimod Exerts only Temporary Antiepileptogenic Effects but Longer-Lasting Positive Effects on Behavior in the WAG/Rij Rat Absence Epilepsy Model
Sign Up to like & getrecommendations! Published in 2017 at "Neurotherapeutics"
DOI: 10.1007/s13311-017-0550-y
Abstract: One of the major challenges in the epilepsy field is identifying disease-modifying drugs in order to prevent or delay spontaneous recurrent seizure onset or to cure already established epilepsy. It has been recently reported that… read more here.
Keywords: wag rij; absence epilepsy; antiepileptogenic effects;
Altered oscillation frequencies in the lateral geniculate complex in the rat model of absence epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy research"
DOI: 10.1016/j.eplepsyres.2019.106212
Abstract: Absence epilepsy (AE) is a neurological disease that manifests in spike-wave discharges not present in healthy neuronal circuits. Mutations in ion channels directly underlying this rhythmic discharge may additionally affect rhythms in multiple brain centres… read more here.
Keywords: geniculate complex; geniculate; lateral geniculate; absence epilepsy ... See more keywords
Identification of a novel variant p.Ser606Gly in SCN3A associated with childhood absence epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2021.106682
Abstract: Sodium (Na+) channels are the basis for action potential generation and propagation, which play a key role in the regulation of neuronal excitability. SCN3A is a gene encoding for sodium channel protein type 3 subunit… read more here.
Keywords: epilepsy; absence; childhood absence; variant ... See more keywords
Sociability impairments in Genetic Absence Epilepsy Rats from Strasbourg: Reversal by the T-type calcium channel antagonist Z944
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.06.022
Abstract: &NA; Childhood absence epilepsy (CAE) is associated with interictal co‐morbid symptoms including abnormalities in social behaviour. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is a model of CAE that exhibits physiological and behavioural alterations characteristic… read more here.
Keywords: z944; sociability; calcium channel; type calcium ... See more keywords
Mutational screening of GABRG2 gene in Pakistani population of Punjab with generalized tonic clonic seizures and children with childhood absence epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Chinese Medical Association"
DOI: 10.1016/j.jcma.2018.05.001
Abstract: Background: Epilepsy is a multifaceted and multistep disorder that disrupts the proper functioning of neurons. It is becoming increasingly clear that the responsiveness of neurons depends on the appropriate trafficking of ions across the channels… read more here.
Keywords: epilepsy; gabrg2; childhood absence; absence epilepsy ... See more keywords
Control of absence epilepsy seizures in specific relay nuclei of thalamus.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.09.008
Abstract: In this paper, we used a classic basal ganglia-corticothalamic model(BGCT) to study the onset and control mechanism of absence epilepsy in specific relay nuclei (SRN) of thalamus. It was found that the seizure state may… read more here.
Keywords: thalamus; mechanism; control; specific relay ... See more keywords
The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11591-5
Abstract: Low-voltage-activated T-type calcium channels are essential contributors to the functioning of thalamocortical neurons by supporting burst-firing mode of action potentials. Enhanced T-type calcium conductance has been reported in the Genetic Absence Epilepsy Rat from Strasbourg… read more here.
Keywords: absence; calnexin; cav3; absence epilepsy ... See more keywords
Neuronal mechanism of a BK channelopathy in absence epilepsy and dyskinesia
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200140119
Abstract: Significance BK channelopathy has been increasingly implicated in diverse neurological disorders, including epilepsy and movement, cognitive, and neurodevelopmental disorders. However, precision medicine to treat BK channelopathy is lacking. We characterized a mouse model carrying a… read more here.
Keywords: epilepsy dyskinesia; absence epilepsy; neuronal mechanism; absence ... See more keywords
Ictal connectivity in childhood absence epilepsy: Associations with outcome
Sign Up to like & getrecommendations! Published in 2018 at "Epilepsia"
DOI: 10.1111/epi.14067
Abstract: The understanding of childhood absence epilepsy (CAE) has been revolutionized over the past decade, but the biological mechanisms responsible for variable treatment outcomes are unknown. Our purpose in this prospective observational study was to determine… read more here.
Keywords: connectivity; childhood absence; absence epilepsy;