Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer
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DOI: 10.1158/0008-5472.can-21-1991
Abstract: A genetically engineered mouse model of NOTCH-mutant SCLC reveals that nonneuroendocrine plasticity persists in the absence of NOTCH, driven by a RUNX2-REST–dependent pathway and innate immune signaling. Neuroendocrine to nonneuroendocrine plasticity supports small cell lung… read more here.
Keywords: notch; nonneuroendocrine plasticity; dependent pathway; plasticity ... See more keywords