RAD51 and RTEL1 compensate telomere loss in the absence of telomerase
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1322
Abstract: Abstract Replicative erosion of telomeres is naturally compensated by telomerase and studies in yeast and vertebrates show that homologous recombination can compensate for the absence of telomerase. We show that RAD51 protein, which catalyzes the… read more here.
Keywords: telomerase; telomere loss; homologous recombination; absence telomerase ... See more keywords
Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase.
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DOI: 10.1534/genetics.119.302391
Abstract: Mecl/ATR and Tell/ATM trigger replicative senescence when telomeres become critically short in the absence of telomerase, but how Tell/ATM promotes senescence is still unclear. Menin et al. studied the functions of Saccharomyces cerevisiae Tel1 in… read more here.
Keywords: replicative senescence; tel1; absence telomerase; senescence ... See more keywords