Absorption, Distribution, Metabolism, and Excretion of a New Herbicide, Epyrifenacil, in Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c04167
Abstract: The metabolic fate of a newly developed herbicide, epyrifenacil, (ethyl[(3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}pyridin-2-yl)oxy]acetate, S-3100), in rats was determined using 14C-labeled epyrifenacil. When it was administered orally to rats at 1 mg/kg, around 73-74% of the dose was absorbed,… read more here.
Keywords: excretion; epyrifenacil; herbicide epyrifenacil; absorption distribution ... See more keywords
Prospective Validation of Machine Learning Algorithms for Absorption, Distribution, Metabolism, and Excretion Prediction: An Industrial Perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00160
Abstract: Absorption, distribution, metabolism, and excretion (ADME), which collectively define the concentration profile of a drug at the site of action, are of critical importance to the success of a drug candidate. Recent advances in machine… read more here.
Keywords: metabolism excretion; learning algorithms; distribution metabolism; machine learning ... See more keywords
Evaluation of in vitro absorption, distribution, metabolism, and excretion and assessment of drug-drug interaction of rucaparib, an orally potent poly(ADP-ribose) polymerase inhibitor
Sign Up to like & getrecommendations! Published in 2020 at "Xenobiotica"
DOI: 10.1080/00498254.2020.1737759
Abstract: Abstract 1. The absorption, distribution, metabolism, elimination, and drug-drug interaction (DDI) potential of the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib was characterised in vitro. 2. Rucaparib showed moderate cellular permeability, moderate human plasma protein binding (70.2%),… read more here.
Keywords: drug; rucaparib; absorption distribution; drug drug ... See more keywords
A phase 1 study to investigate the absorption, distribution, metabolism and excretion of brepocitinib in healthy males using a 14 C-microdose approach.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15786
Abstract: AIMS Brepocitinib is a tyrosine kinase 2/Janus kinase 1 inhibitor being investigated for the treatment of several autoimmune diseases. This study assessed the absorption, distribution, metabolism and excretion of oral brepocitinib, and the absolute oral… read more here.
Keywords: period; brepocitinib; dose; absorption distribution ... See more keywords
Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance
Sign Up to like & getrecommendations! Published in 2023 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.001006
Abstract: Human absorption, distribution, metabolism, and excretion (hADME) studies represent one of the most important clinical studies in terms of obtaining a comprehensive and quantitative overview of the total disposition of a drug. This article will… read more here.
Keywords: metabolism excretion; metabolism; distribution metabolism; absorption distribution ... See more keywords
The Interplay between Pharmacokinetics and Pharmacodynamics
Sign Up to like & getrecommendations! Published in 2017 at "Pediatrics in Review"
DOI: 10.1542/pir.2016-0101
Abstract: 1. Tracy L. Sandritter, PharmD, BCPPS*,† 2. Matthew McLaughlin, MD, MS† 3. Michael Artman, MD‡ 4. Jennifer Lowry, MD† 1. *University of Missouri–Kansas City School of Pharmacy, Kansas City, MO 2. †Division of Clinical Pharmacology,… read more here.
Keywords: kansas city; drug; interplay pharmacokinetics; pharmacokinetics pharmacodynamics ... See more keywords
Absorption, distribution and elimination behaviours of cadmium treated by in vitro DIN from WLP residue using SAAM II modeling
Sign Up to like & getrecommendations! Published in 2018 at "Sains Malaysiana"
DOI: 10.17576/jsm-2018-4703-23
Abstract: Mathematically, the human alimentary tract organs were simplified in the model structure as separate compartments with pathways of transfer that are kinetically homogenous and equally distributed. The development of gastro-compartment model follows the first order… read more here.
Keywords: absorption distribution; model; cadmium; distribution elimination ... See more keywords
Absorption, distribution, metabolism and elimination of 14C-ETX0914, a novel inhibitor of bacterial type-II topoisomerases in rodents
Sign Up to like & getrecommendations! Published in 2017 at "Xenobiotica"
DOI: 10.3109/00498254.2016.1156186
Abstract: Abstract 1. ETX0914 is a novel bacterial topoisomerase inhibitor that has a novel mode-of-inhibition and is in clinical development for the treatment of infections caused by Neisseria gonorrhoeae. 2. The in vitro biotransformation studies of ETX0914 using… read more here.
Keywords: etx0914 novel; 14c etx0914; etx0914; inhibitor ... See more keywords
A machine learning-based approach to ERα bioactivity and drug ADMET prediction
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1087273
Abstract: By predicting ERα bioactivity and mining the potential relationship between Absorption, Distribution, Metabolism, Excretion, Toxicity (ADMET) attributes in drug research and development, the development efficiency of specific drugs for breast cancer will be effectively improved… read more here.
Keywords: metabolism excretion; distribution metabolism; absorption distribution; prediction ... See more keywords
Absorption and Distribution of Toltrazuril and Toltrazuril Sulfone in Plasma, Intestinal Tissues and Content of Piglets after Oral or Intramuscular Administration
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26185633
Abstract: Piglet coccidiosis due to Cystoisospora suis is a major cause of diarrhea and poor growth worldwide. It can effectively be controlled by application of toltrazuril (TZ), and oral formulations have been licensed for many years.… read more here.
Keywords: plasma intestinal; intestinal tissues; application; toltrazuril ... See more keywords
Homology Modeling, Docking, Absorption, Distribution, Metabolism, Excretion and Toxicity Studies and Prediction of Deleterious Non-Synonymous Single Nucleotide Polymorphisms (Nssnps) of Thiamin Phosphate Synthase: A Potential Drug Target in Plasmodium Falciparum
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Pharmaceutical Sciences"
DOI: 10.36468/pharmaceutical-sciences.692
Abstract: The drug resistance in malarial parasites is increasingly emerging, hence it is essential to discover and develop alternative anti-malarial agents against both new and established drug targets. One of such possible drug targets is thiamine… read more here.
Keywords: drug; absorption distribution; metabolism excretion; distribution metabolism ... See more keywords