In vitro–In vivo Relationship and Bioequivalence Prediction for Modified-Release Capsules Based on a PBPK Absorption Model
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DOI: 10.1208/s12249-019-1566-x
Abstract: A physiologically based pharmacokinetic (PBPK) absorption model was developed in GastroPlus™ based on data on intravenous, immediate-release (IR), and modified-release (MR) drug products. The predictability of the model was evaluated by comparing predicted and observed… read more here.
Keywords: pbpk absorption; model; modified release; absorption model ... See more keywords
Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children
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DOI: 10.3390/pharmaceutics14010172
Abstract: The higher skin surface area to body weight ratio in children and the prematurity of skin in neonates may lead to higher chemical exposure as compared to adults. The objectives of this study were: (i)… read more here.
Keywords: absorption model; dermal absorption; age dependent; development ... See more keywords
Uncertainty of atmospheric microwave absorption model: impact on ground-based radiometer simulations and retrievals
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DOI: 10.5194/acp-18-15231-2018
Abstract: Abstract. This paper presents a general approach to quantify absorption model uncertainty due to uncertainty in the underlying spectroscopic parameters. The approach is applied to a widely used microwave absorption model (Rosenkranz, 2017) and radiative… read more here.
Keywords: absorption model; microwave; uncertainty; line ... See more keywords